Results 81 to 90 of about 622,206 (305)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Itinerarios de aprendizaje flexibles basados en mapas conceptuales

Journal of New Approaches in Educational Research, 2015
Se estudia el uso de itinerarios de aprendizaje  basados en mapas conceptuales como una propuesta para un diseño instruccional más flexible que potencie el aprendizaje y se centre en el estudiante, generando procesos no lineales, caracterizando sus ...
Olga Lucía Agudelo, Jesus Salinas Ibáñez   +1 more
doaj   +1 more source

Distortions in memory for visual displays [PDF]

Systematic errors in perception and memory present a challenge to theories of perception and memory and to applied psychologists interested in overcoming them as well. A number of systematic errors in memory for maps and graphs are reviewed, and they are
Tversky, Barbara
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Digital conceptual mapping for enhancing mathematical concept formation and creative mathematical problem-solving through cognitive flexibility skills: a mixed methods study

Cogent Education
The study investigates the impact of digital conceptual mapping strategies on the learner’s mathematical academic performance in terms of mathematical concept formation and creative problem-solving skills based on the skill of flexibility.
Ahmed Elhilal
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Quantitative assessment of the scope of content of selected topographic maps of Polish lands from the 19th and the first half of the 20th century

Polish Cartographical Review, 2017
The author presents an overview of the scope of content of selected topographic maps of Polish lands from the 19th and the first half of the 20th century in its quantitative aspect.
Panecki Tomasz
doaj   +1 more source

Leveling the Field: Talking Levels in Cognitive Science [PDF]

, 2016
Talk of levels is everywhere in cognitive science. Whether it is in terms of adjudicating longstanding debates or motivating foundational concepts, one cannot go far without hearing about the need to talk at different ‘levels’.
Brook, Andrew, Kersten, Luke, West, Robert   +2 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source