Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. [PDF]
PLoS Genetics, 2013 The heteropentameric condensin complexes have been shown to participate in mitotic chromosome condensation and to be required for unperturbed chromatid segregation in nuclear divisions.
Sabine Herzog +5 more
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Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission [PDF]
Cell Reports, 2020 Summary: Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear.
Rajan Pandey +18 more
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Decoding Mitotic Chromosome Assembly: Three Rules Governing Condensin–Cohesin Engagement [PDF]
ResearchMitotic chromosome formation depends on coordinated SMC complex activities, yet how condensin engages cohesin during this process remains unclear. Samejima et al.
Haiyan Yan, Xinyu Zhou, Fangwei Wang
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Functional interplay between condensin I and topoisomerase IIα in single-molecule DNA compaction [PDF]
Nature CommunicationsCondensin I and topoisomerase IIα (topo IIα) are chromosomal ATPases essential for mitotic chromosome assembly. Mechanistically how the two ATPases cooperate to assemble mitotic chromosomes remains unknown.
Yuko Tsubota +7 more
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A phospho-switch to trigger mitotic chromosome condensation [PDF]
Biology DirectOne of the most eye-catching events in cell biology is the condensation of chromosomes. During mitosis, the diffuse interphase chromatin rearranges into compact, rod-shaped chromosomes that can be precisely segregated between the daughter cells.
Alessandro Borsellini
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Molecular mechanism of condensin I activation by KIF4A [PDF]
The EMBO JournalDuring mitosis, the condensin I and II complexes compact chromatin into chromosomes. Loss of the chromokinesin, KIF4A, results in reduced condensin I association with chromosomes, but the molecular mechanism behind this phenotype is unknown.
Erin E Cutts +3 more
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The length and strength of compartmental interactions are modulated by condensin II activity. [PDF]
PLoS GeneticsThe spatial organization of the genome is crucial for its function and integrity. Although the ring-like SMC complex condensin II has a well-documented role in organizing mitotic chromosomes, its function in interphase chromatin structure has remained ...
Randi Isenhart +7 more
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Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes [PDF]
Cell Reports, 2017 How metazoan genomes are structured at the nanoscale in living cells and tissues remains unknown. Here, we adapted a quantitative FRET (Förster resonance energy transfer)-based fluorescence lifetime imaging microscopy (FLIM) approach to assay nanoscale ...
David Llères +5 more
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Condensin IDC, DPY-21, and CEC-4 maintain X chromosome repression in C. elegans. [PDF]
PLoS GeneticsDosage compensation in Caenorhabditis elegans equalizes X-linked gene expression between XX hermaphrodites and XO males. The process depends on a condensin-containing dosage compensation complex (DCC), which binds the X chromosomes in hermaphrodites to ...
Jessica Trombley +4 more
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Condensin II interacts with BLM helicase in S phase to maintain genome stability [PDF]
Communications BiologyVertebrates possess two condensins, I and II, that are essential for chromosome condensation and segregation. Condensin II has also been implicated in maintaining genome integrity outside of mitosis, though the underlying mechanisms are unclear. Here, we
Brian Rodemoyer +3 more
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