Results 101 to 110 of about 10,706 (194)

Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina. [PDF]

, 2009
BACKGROUND: The condensation of chromosomes and correct sister chromatid segregation during cell division is an essential feature of all proliferative cells.

core   +1 more source

Multiple roles of Condensins: a complex story [PDF]

Biology of the Cell, 2004
Summry— Condensins are pentameric complexes that were initially described as being involved in the dynamics of chromosomes during mitosis. It has been recently established that two related complexes (Condensin I and Condensin II) contribute to this process.
Legagneux, Vincent, Cubizolles, Fabien, Watrin, Erwan   +2 more
openaire   +2 more sources

RNAP II antagonizes mitotic chromatin folding and chromosome segregation by condensin

Cell Reports
Summary: Condensin shapes mitotic chromosomes by folding chromatin into loops, but whether it does so by DNA-loop extrusion remains speculative. Although loop-extruding cohesin is stalled by transcription, the impact of transcription on condensin, which ...
Jérémy Lebreton, Léonard Colin, Elodie Chatre, Pascal Bernard   +3 more
doaj   +1 more source

Chromosome Territories Meet a Condensin

PLoS Genetics, 2012
In human diploid cells, 23 pairs of chromosomes become recognizable as a discrete set of rod-shaped entities during the mitotic stage of the cell cycle. Upon exit from mitosis, they decondense and are packed together into the nucleus, in which individual chromosomes are no longer discernible.
openaire   +4 more sources

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

MedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei   +10 more
wiley   +1 more source

Signatures of selection detected from whole‐genome sequencing indicate that the small body size in dwarf rabbit breeds is caused by polygenic effects with a few major loci

Animal Genetics, Volume 56, Issue 4, August 2025.
Abstract Early genetic studies have suggested that body size in rabbits can be considered a quantitative trait. Several rabbit breeds can be distinguished based on body size, including a few dwarf breeds differentiated by other morphological characteristics.
Samuele Bovo, Miguel Carneiro, Anisa Ribani, Matteo Bolner, Valeria Taurisano, Giuseppina Schiavo, Michele Schiavitto, Francesca Bertolini, Luca Fontanesi   +8 more
wiley   +1 more source

Taking cohesin and condensin in context

PLOS Genetics, 2018
Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome.
Kobe C. Yuen, Jennifer L. Gerton
openaire   +3 more sources

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, Volume 12, Issue 23, June 20, 2025.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

RPL35A Downregulation Suppresses Hepatocellular Carcinoma Cell Proliferation via NCAPG2 Inactivation

Cancer Medicine, Volume 14, Issue 12, June 2025.
ABSTRACT Background Hepatocellular carcinoma (HCC) is a highly aggressive cancer with a poor prognosis. The molecular mechanisms underlying HCC progression remain poorly understood, prompting the need for novel therapeutic targets. RPL35A, a component of the 60S large ribosomal subunit, is a ribosomal protein involved in ribosome biogenesis and protein
Liang Chen, Yujie Lin, Yu Lai, Yanshan Li, Tao Chen, Xingxi Luo, Yibiao Ye   +6 more
wiley   +1 more source

ISWI remodeling complexes in Xenopus egg extracts: Identification as major chromosomal components that are regulated by INCENP-aurora B [PDF]

, 2002
We previously characterized major components of mitotic chromosomes assembled in Xenopus laevis egg extracts and collectively referred to them as Xenopuschromosome–associated polypeptides (XCAPs).
Hirano, T., Kobayashi, R., Losada, A., MacCallum, D. E.   +3 more
core   +2 more sources