Results 121 to 130 of about 10,706 (194)

Chromosome structure: improved immunolabeling for electron microscopy [PDF]

, 2018
To structurally dissect mitotic chromosomes, we aim to position along the folded chromatin fiber proteins involved in long-range order, such as topoisomerase IIα (topoIIα) and condensin.
Eltsov, Michail, Laemmli, Ulrich, Maeshima, Kazuhiro   +2 more
core  

Condensation transition in DNA-polyaminoamide dendrimer fibers studied using optical tweezers [PDF]

, 2006
When mixed together, DNA and polyaminoamide (PAMAM) dendrimers form fibers that condense into a compact structure. We use optical tweezers to pull condensed fibers and investigate the decondensation transition by measuring force-extension curves (FECs ...
C. Bustamante, C. G. Baumann, F. Ritort, G. I. Bell, J. F. Marko, S. B. Smith, S. Mihardja   +6 more
core   +2 more sources

A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure.

PLoS Genetics, 2019
The NAD+-dependent histone deacetylase Sir2 was originally identified in Saccharomyces cerevisiae as a silencing factor for HML and HMR, the heterochromatic cassettes utilized as donor templates during mating-type switching.
Mingguang Li, Ryan D Fine, Manikarna Dinda, Stefan Bekiranov, Jeffrey S Smith   +4 more
doaj   +1 more source

A simple biophysical model emulates budding yeast chromosome condensation

eLife, 2015
Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb-long nucleosome chain, the size of a budding yeast ...
Tammy MK Cheng, Sebastian Heeger, Raphaël AG Chaleil, Nik Matthews, Aengus Stewart, Jon Wright, Carmay Lim, Paul A Bates, Frank Uhlmann   +8 more
doaj   +1 more source

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2.

, 2020
In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but poorly understood roles in the formation of chromosome axial elements (AEs)
Biswas, U., Eichele, G., Hempel, K., Jessberger, R., Kühnel, A., McNicoll, F., Whelan, G.   +6 more
core   +1 more source

Condensin wraps it up

The Journal of Cell Biology, 2002
![][1] Condensin introduces supercoils (left) by wrapping DNA around itself (right). Hirano/Elsevier Packing DNA into a nucleus is no mean feat. Now, David Bazett-Jones (Hospital for Sick Children, Toronto, Canada), Keiji Kimura, and Tatsuya Hirano (Cold Spring Harbor Laboratory,
openaire   +2 more sources

Chromosome compaction is triggered by an autonomous DNA-binding module within condensin

Cell Reports
Summary: The compaction of chromatin into mitotic chromosomes is essential for faithful transmission of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated by the condensin complex, though the exact mechanism used to ...
Alyssa Pastic, Michael L. Nosella, Annahat Kochhar, Zi Hao Liu, Julie D. Forman-Kay, Damien D’Amours   +5 more
doaj   +1 more source

Cdk1-dependent phosphorylation of KIF4A at S1186 triggers lateral chromosome compaction during early mitosis.

PLoS ONE, 2018
Chromosome organization during cell division is achieved through the timely association of proteins with chromatin and is regulated by protein phosphorylation.
Hideaki Takata, Marliza Madung, Kaoru Katoh, Kiichi Fukui   +3 more
doaj   +1 more source

A SILAC-based Approach Identifies Substrates of Caspase-dependent Cleavage upon TRAIL-induced Apoptosis

, 2013
The extracellular ligand-induced extrinsic pathway of apoptosis is executed via caspase protease cascades that activate downstream effectors by means of site-directed proteolysis.
Graumann, J., Mann, M., Schaab, C., Stoehr, G.   +3 more
core   +1 more source

Condensin II activation by M18BP1

Molecular Cell
ABSTRACTCondensin complexes promote the drastic spatial rearrangement of the genome upon mitotic entry. Condensin II initiates chromosome condensation in early mitosis. To prevent chromosome condensation during interphase, condensin II is inhibited by MCPH1, but the mechanism is unknown.
Alessandro Borsellini, Duccio Conti, Erin Cutts, Rebecca J. Harris, Kai Walstein, Andrea Graziadei, Valentina Cecatiello, Tom F. Aarts, Ren Xie, Abdelghani Mazouzi, Sushweta Sen, Claire Hoencamp, Richard Pleuger, Sabrina Ghetti, Lina Oberste-Lehn, Dongqing Pan, Tanja Bange, Judith H.I. Haarhuis, Anastassis Perrakis, Thijn R. Brummelkamp, Benjamin D. Rowland, Andrea Musacchio, Alessandro Vannini   +22 more
openaire   +3 more sources