Results 11 to 20 of about 10,706 (194)

Condensin-Condensin Interactions Facilitate Mitotic Chromosome Assembly in Xenopus Egg Extracts. [PDF]

Genes Cells
ABSTRACT Condensins are large protein complexes that play a central role in mitotic chromosome assembly in eukaryotes. Our previous mutational analyses of condensin I, combined with Xenopus egg cell‐free extracts, provided evidence that dynamic condensin‐condensin ...
Kinoshita K, Aizawa Y, Hirano T.
europepmc   +3 more sources

Contrasting roles of condensin I and condensin II in mitotic chromosome formation [PDF]

Journal of cell science, 2012
© 2012. Published by The Company of Biologists LtdIn vertebrates, two condensin complexes exist, condensin I and condensin II, which have differing but unresolved roles in organizing mitotic chromosomes.
Abe, Adams, Adolph, Anderson, Baron, Baumann, Belmont, Bernad, Buerstedde, Chan, Cooke, Csankovszki, Csankovszki, D'Ambrosio, Dej, Earnshaw, Earnshaw, Fazzio, Fedorov, Gasser, Gerlich, Gossen, Graumann, Gustafsson, Hagstrom, Hilwig, Hirano, Hirano, Hirano, Hirota, Hudson, Hudson, Hudson, Jaqaman, Kelly, Kireeva, Kurasawa, Lipp, Maeshima, Markaki, Moser, Murnion, Ohta, Oliveira, Ono, Ono, Paulson, Pertile, Ribeiro, Ruchaud, Saitoh, Samejima, Samoshkin, Savvidou, Shintomi, Siddiqui, Spence, Stear, Strukov, Strunnikov, Takemoto, Vagnarelli, Volkov, Wang, Wang, Watrin, Wignall, Yamagishi, Yanagida, Yoshimura   +69 more
core   +7 more sources

Chromosome shaping by two condensins [PDF]

Cell Cycle, 2004
It remains a big challenge in modern cell biology to determine the mechanism by which a discrete set of rod-shaped chromosomes is assembled from an amorphous mass of interphase chromatin.
Hirano, T.
core   +4 more sources

Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells [PDF]

Scientific Reports
Cohesin and condensin, two related protein complexes, play essential roles in ensuring the accurate segregation of the genome into daughter cells during cell division. However, the interaction between cohesin and condensin in embryonic stem cells remains
Eui-Hwan Choi, Keun P. Kim
doaj   +2 more sources

Molecular mechanism targeting condensin for chromosome condensation [PDF]

The EMBO Journal
Genomes are organised into DNA loops by the Structural Maintenance of Chromosomes (SMC) proteins. SMCs establish functional chromosomal sub-domains for DNA repair, gene expression and chromosome segregation, but how SMC activity is specifically targeted ...
Menglu Wang, Daniel Robertson, Juan Zou, Christos Spanos, Juri Rappsilber, Adele L Marston   +5 more
doaj   +2 more sources

Where, When, and How? Integrating Spatiotemporal Cues in Cell Division. [PDF]

Bioessays
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Cirillo L, Konthalapalli H, Alfieri C, Pines J.   +3 more
europepmc   +2 more sources

Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit

eLife, 2022
Condensin I is a pentameric protein complex that plays an essential role in mitotic chromosome assembly in eukaryotic cells. Although it has been shown that condensin I loading is mitosis specific, it remains poorly understood how the robust cell cycle ...
Shoji Tane, Keishi Shintomi, Kazuhisa Kinoshita, Yuko Tsubota, Makoto M Yoshida, Tomoko Nishiyama, Tatsuya Hirano   +6 more
doaj   +1 more source

An SMC-like protein binds and regulates Caenorhabditis elegans condensins. [PDF]

PLoS Genetics, 2017
Structural Maintenance of Chromosomes (SMC) family proteins participate in multisubunit complexes that govern chromosome structure and dynamics.
Lucy Fang-I Chao, Meha Singh, James Thompson, John R Yates, Kirsten A Hagstrom   +4 more
doaj   +1 more source

Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays

eLife, 2022
In vertebrates, condensin I and condensin II cooperate to assemble rod-shaped chromosomes during mitosis. Although the mechanism of action and regulation of condensin I have been studied extensively, our corresponding knowledge of condensin II remains ...
Makoto M Yoshida, Kazuhisa Kinoshita, Yuuki Aizawa, Shoji Tane, Daisuke Yamashita, Keishi Shintomi, Tatsuya Hirano   +6 more
doaj   +1 more source

Levels of Ycg1 Limit Condensin Function during the Cell Cycle. [PDF]

PLoS Genetics, 2016
During mitosis chromosomes are condensed to facilitate their segregation, through a process mediated by the condensin complex. Although several factors that promote maximal condensin activity during mitosis have been identified, the mechanisms that ...
Tyler W Doughty, Heather E Arsenault, Jennifer A Benanti   +2 more
doaj   +1 more source