Results 21 to 30 of about 10,706 (194)
Cohesin causes replicative DNA damage by trapping DNA topological stress [PDF]
, 2020 DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress ...
Baxter, Jonathan +2 more
core +1 more source
Small Molecule Condensin Inhibitors [PDF]
ACS Infectious Diseases, 2018 Condensins play a unique role in orchestrating the global folding of the chromosome, an essential cellular process, and contribute to human disease and bacterial pathogenicity. As such, they represent an attractive and as yet untapped target for diverse therapeutic interventions.
Hang Zhao +5 more
openaire +2 more sources
Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts [PDF]
Open Biology, 2019 Condensin is an essential component of chromosome dynamics, including mitotic chromosome condensation and segregation, DNA repair, and development. Genome-wide localization of condensin is known to correlate with transcriptional activity.
Norihiko Nakazawa +2 more
doaj +1 more source
Condensin action and compaction [PDF]
Current Genetics, 2018 Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination.
Matthew Robert Paul +2 more
openaire +2 more sources
Genome Biology, 2020 Background Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chromatin interactions in mitosis ...
Yasutaka Kakui +7 more
doaj +1 more source
Chromosome Organization: Original Condensins [PDF]
Current Biology, 2014 Two new studies reveal the main actors involved in the resolution and segregation of newly replicated origins in bacteria. These results have important implications for our understanding of the mechanisms involved in precisely coordinating chromosome organization, segregation and replication.
Diego I. Cattoni +2 more
openaire +2 more sources
Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1. [PDF]
PLoS ONE, 2011 Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair.
Xiangduo Kong +6 more
doaj +1 more source
Condensins under the microscope [PDF]
Journal of Cell Biology, 2018 Condensins are key players in mitotic chromosome condensation. Using an elegant combination of state-of-the-art imaging techniques, Walther et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201801048) counted the number of Condensins, examined their behaviors on human mitotic chromosomes, and integrated the quantitative data to propose a new ...
Kazuhiro Maeshima +2 more
openaire +3 more sources
Dangerous liaisons: MYCN meets condensins [PDF]
Cell Cycle, 2014 (2014). Dangerous liaisons: MYCN meets condensins. Cell Cycle: Vol. 13, No. 8, pp. 1225-1226.
Y. J. Achar, M. Foiani
openaire +3 more sources
Condensin I reveals new insights on mouse meiotic chromosome structure and dynamics. [PDF]
PLoS ONE, 2007 Chromosome shaping and individualization are necessary requisites to warrant the correct segregation of genomes in either mitotic or meiotic cell divisions. These processes are mainly prompted in vertebrates by three multiprotein complexes termed cohesin
Alberto Viera +6 more
doaj +1 more source