Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold. [PDF]
PLoS ONE, 2017 Kinesin family member 4 (KIF4) and condensins I and II are essential chromosomal proteins for chromosome organization by locating primarily to the chromosome scaffold.
Rawin Poonperm +3 more
doaj +1 more source
eLife, 2023 The localization of condensin along chromosomes is crucial for their accurate segregation in anaphase. Condensin is enriched at telomeres but how and for what purpose had remained elusive.
Léonard Colin +12 more
doaj +1 more source
The human Cranio Facial Development Protein 1 (Cfdp1) gene encodes a protein required for the maintenance of higher-order chromatin organization [PDF]
, 2017 The human Cranio Facial Development Protein 1 (Cfdp1) gene maps to chromosome 16q22.2-q22.3 and encodes the CFDP1 protein, which belongs to the evolutionarily conserved Bucentaur (BCNT) family.
Atterrato, Maria Teresa +5 more
core +3 more sources
Chromosome Segregation: Monopolin Attracts Condensin [PDF]
Current Biology, 2011 To segregate chromosomes properly, the cell must prevent merotely, an error that occurs when a single kinetochore is attached to microtubules emanating from both spindle poles. Recent evidence suggests that cooperation between Pcs1/Mde4 and condensin complexes plays an important role in preventing merotely.
Dudas, Andrej +2 more
openaire +3 more sources
Nucleic Acids Research, 2022 Abstract Condensin I and condensin II are multi-subunit complexes that are known for their individual roles in genome organization and preventing genomic instability. However, interactions between condensin I and condensin II subunits and cooperative roles for condensin I and condensin II, outside of their genome organizing functions ...
Jacqueline R Ward +7 more
openaire +2 more sources
Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III.
PLoS Genetics, 2023 Despite recent advances in single-molecule and structural analysis of condensin activity in vitro, mechanisms of functional condensin loading and loop extrusion that lead to specific chromosomal organization remain unclear.
Manikarna Dinda +6 more
doaj +1 more source
Cell-Cycle Regulation of Dynamic Chromosome Association of the Condensin Complex
Cell Reports, 2018 Summary: Eukaryotic cells inherit their genomes in the form of chromosomes, which are formed from the compaction of interphase chromatin by the condensin complex. Condensin is a member of the structural maintenance of chromosomes (SMC) family of ATPases,
Rahul Thadani +4 more
doaj +1 more source
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface
eLife, 2021 Dramatic change in chromosomal DNA morphology between interphase and mitosis is a defining features of the eukaryotic cell cycle. Two types of enzymes, namely cohesin and condensin confer the topology of chromosomal DNA by extruding DNA loops.
Martin Houlard +9 more
doaj +1 more source
Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA [PDF]
, 2015 SMC5/6 is a highly conserved protein complex related to cohesin and condensin, which are the key components of higher-order chromatin structures. The SMC5/6 complex is essential for proliferation in yeast and is involved in replication fork stability and
Adamus, Marek +10 more
core +2 more sources
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]
, 2019 Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G. +5 more
core +2 more sources