Results 51 to 60 of about 10,706 (194)

Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast.

PLoS Genetics, 2020
Correct bioriented attachment of sister chromatids to the mitotic spindle is essential for chromosome segregation. In budding yeast, the conserved protein shugoshin (Sgo1) contributes to biorientation by recruiting the protein phosphatase PP2A-Rts1 and ...
Galal Yahya, Yehui Wu, Karolina Peplowska, Jennifer Röhrl, Young-Min Soh, Frank Bürmann, Stephan Gruber, Zuzana Storchova   +7 more
doaj   +1 more source

Condensin DC loads and spreads from recruitment sites to create loop-anchored TADs in C. elegans

eLife, 2022
Condensins are molecular motors that compact DNA via linear translocation. In Caenorhabditis elegans, the X-chromosome harbors a specialized condensin that participates in dosage compensation (DC).
Jun Kim, David S Jimenez, Bhavana Ragipani, Bo Zhang, Lena A Street, Maxwell Kramer, Sarah E Albritton, Lara H Winterkorn, Ana K Morao, Sevinc Ercan   +9 more
doaj   +1 more source

“Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines [PDF]

, 2014
The absolute necessity to resolve every intertwine between the two strands of the DNA double helix provides a massive challenge to the cellular processes that duplicate and segregate chromosomes.
Bartkova, Baumann, Baxter, Baxter, Baxter, Bermejo, Bester, Branzei, Branzei, Brill, Burrell, Bzymek, Cejka, Champoux, Champoux, Chan, Chan, Chang, Chu, Crisona, Cuylen, Cuylen, Delbrück, Di Micco, Dominguez-Sola, Ekholm-Reed, Farcas, Fernandez, Gandhi, Gangloff, Gerlich, Germann, Giet, Goodwin, Gorgoulis, Halazonetis, Hardy, Hawkins, Hendzel, Hiasa, Hiasa, Hiasa, Hills, Hirano, Hirano, Hirano, Holm, Hsu, Jonathan Baxter, Kato, Kato, Khodursky, Khodursky, Kimura, Kimura, Kitamura, Koshland, Kreuzer, Kueng, Lavoie, Leman, Lucas, Mantiero, Maresca, Marston, Martinez-Robles, Matos, McClendon, McClintock, McGlynn, McGuffee, Mullen, Naughton, Neelsen, Newport, Oliveira, Ono, Paulson, Peter, Postow, Rattner, Rybenkov, Rybenkov, Sakaguchi, Samejima, Schoeffler, Schvartzman, Shamu, Shintomi, Spruck, Stuchinskaya, Sullivan, Sundin, Sundin, Suski, Symington, Szakal, Tedeschi, Temime-Smaali, Toledo, Vologodskii, Vos, Wang, Wang, Wang, Watson, Watson, Wei, Wilkins, Zechiedrich, Zechiedrich   +110 more
core   +1 more source

Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]

, 2015
SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Alipour, Anderson, Arumugam, Byung-Ha Oh, Bürmann, Cheolhee Kim, Chiu, Christopher P. Toseland, Cuylen, Frank Bürmann, Fuentes-Perez, Griese, Griese, Gruber, Gruber, Haering, Haering, Hansol Lee, Hirano, Hirano, Ho-Chul Shin, Ho Min Kim, Huis in ‘t Veld, Hura, Kimura, Ku, Kurze, Kyeong Sik Jin, Li, Mamoru Sato, Marie-Laure Durand-Diebold, Mascarenhas, Matoba, Melby, Min-Seok Kong, Moreno-Herrero, Nam Ki Lee, Nasmyth, Nasmyth, Nolivos, Oldham, Onn, Rambo, Rambo, Revenkova, Schleiffer, Soo Jin Kim, Soppa, Stephan Gruber, Takashi Oda, Thadani, Vos, Weitzer, Williams, Woo, Yamazoe, Yeon-Gil Kim, Young-Min Soh   +57 more
core   +6 more sources

Could Condensin Scaffold the Mitotic Chromosome? [PDF]

Cell Cycle, 2004
One of the most remarkable and yet poorly understood events during the cell cycle is how dispersed chromatin fragments are transformed into chromosomes every time cells undergo mitosis. It has been postulated that mitotic chromosomes might contain an axial scaffold that is involved in condensation but its molecules and structure have remained elusive ...
Paula A, Coelho, Joana, Queiroz-Machado, Claudio E, Sunkel   +2 more
openaire   +2 more sources

Condensin-driven loop extrusion on supercoiled DNA [PDF]

Nature Structural & Molecular Biology, 2021
AbstractCondensin, a structural maintenance of chromosomes (SMC) complex, has been shown to be a molecular motor protein that organizes chromosomes by extruding loops of DNA. In cells, such loop extrusion is challenged by many potential conflicts, e.g., the torsional stresses that are generated by other DNA-processing enzymes.
Eugene Kim, Alejandro Martin Gonzalez, Biswajit Pradhan, Jaco van der Torre, Cees Dekker   +4 more
openaire   +5 more sources

RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes. [PDF]

PLoS Genetics, 2014
Condensin-mediated chromosome condensation is essential for genome stability upon cell division. Genetic studies have indicated that the association of condensin with chromatin is intimately linked to gene transcription, but what transcription-associated
Pénélope Legros, Amélie Malapert, Sho Niinuma, Pascal Bernard, Vincent Vanoosthuyse   +4 more
doaj   +1 more source

A pathway for mitotic chromosome formation [PDF]

, 2018
Mitotic chromosomes fold as compact arrays of chromatin loops. To identify the pathway of mitotic chromosome formation, we combined imaging and Hi-C analysis of synchronous DT40 cell cultures with polymer simulations.
Dekker, Job, Earnshaw, William C., Gibcus, Johan H., Goloborodko, Anton, Kanemaki, Masato T, Mirny, Leonid A, Naumova, Natalia, Nuebler, Johannes, Paulson, James R., Samejima, Itaru, Samejima, Kumiko, Xie, Linfeng   +11 more
core   +1 more source

Plant condensin II is required for the correct spatial relationship between centromeres and rDNA arrays

Nucleus, 2019
Plants possess the structural maintenance of chromosome (SMC) protein complexes cohesin, condensin, and SMC5/6, which function in fundamental biological processes such as sister chromatid cohesion, chromosome condensation and segregation, and damaged DNA
Takuya Sakamoto, Tomoya Sugiyama, Tomoe Yamashita, Sachihiro Matsunaga   +3 more
doaj   +1 more source

Principles of meiotic chromosome assembly revealed in S. cerevisiae [PDF]

, 2019
During meiotic prophase, chromosomes organise into a series of chromatin loops emanating from a proteinaceous axis, but the mechanisms of assembly remain unclear.
A Goloborodko, A Hayashi, A Lengronne, A Storlazzi, A Tedeschi, AL Sanborn, AV Smith, B Bonev, D Thacker, D Zickler, E Alipour, E Crane, E Trelles-Sticken, EF Glynn, EP Nora, EP Nora, F Klein, G Fudenberg, G Fudenberg, G Fudenberg, G Wutz, GA Busslinger, H Jin, H Muller, H Tjong, H Wong, J Dekker, J Dekker, J Gassler, J Li, JA Carballo, JF Marko, JHI Haarhuis, JM Belton, JR Dixon, K Challa, K Nasmyth, KG Alavattam, L Lazar-Stefanita, L Patel, L Xu, M Ito, M Merkenschlager, M Sym, M Sym, MN Conrad, N Naumova, N Servant, NJ Petela, NM Hollingsworth, O Crawley, P Eastman, P Eastman, P Kerpedjiev, PB Møens, Q Jin, S Heinz, S Maleki, S Panizza, SA Schalbetter, SSP Rao, SSP Rao, T Mizuguchi, T Sakuno, TS Hsieh, VV Subramanian, W Schwarzer, Y Blat, Y Kakui, Y Wang   +69 more
core   +2 more sources