Results 71 to 80 of about 10,706 (194)
Condensin function in dosage compensation [PDF]
Epigenetics, 2009 Dosage compensation is an essential process that equalizes X-linked gene dosage between the sexes. In the worm Caenorhabditis elegans, a complex of proteins called the dosage compensation complex (DCC) binds both X chromosomes in hermaphrodites to downregulate gene expression two-fold and hence to reduce X-linked gene expression levels equal to that in
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Insect Molecular Biology, EarlyView.Duplication of vas genes is universally observed in aphids, and phylogenetic analysis indicates that this event predates the divergence of Aphididae and Phylloxeridae. Ap‐vas1 is germline‐specific, whereas Ap‐vas2–4 exhibit somatic expression, indicating functional divergence during aphid embryogenesis.
Gee‐Way Lin +4 more
wiley +1 more source
Cell Reports, 2014 Condensin is a central regulator of mitotic genome structure with mutants showing poorly condensed chromosomes and profound segregation defects. Here, we identify NCT, a complex comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02 ...
Hyun-Soo Kim +18 more
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A new family of bacterial condensins [PDF]
Molecular Microbiology, 2011 SummaryCondensins play a central role in global chromatin organization. In bacteria, two families of condensins have been identified, the MukBEF and SMC–ScpAB complexes. Only one of the two complexes is usually found in a given species, giving rise to a paradigm that a single condensin organizes bacterial chromosomes.
Zoya M, Petrushenko +2 more
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Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
Advanced Science, Volume 13, Issue 6, 30 January 2026.This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha +11 more
wiley +1 more source
Dynamic molecular linkers of the genome: the first decade of SMC proteins [PDF]
, 2005 Structural maintenance of chromosomes (SMC) proteins are chromosomal ATPases, highly conserved from bacteria to humans, that play fundamental roles in many aspects of higher-order chromosome organization and dynamics.
Hirano, T., Losada, A.
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Condensin Regulates the Stiffness of Vertebrate Centromeres [PDF]
Molecular Biology of the Cell, 2009 When chromosomes are aligned and bioriented at metaphase, the elastic stretch of centromeric chromatin opposes pulling forces exerted on sister kinetochores by the mitotic spindle. Here we show that condensin ATPase activity is an important regulator of centromere stiffness and function.
Ribeiro, S.A. +10 more
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Cti1/C1D interacts with condensin SMC hinge and supports the DNA repair function of condensin [PDF]
Proceedings of the National Academy of Sciences, 2004 Condensin is a conserved five-subunit complex containing two SMC (structural maintenance of chromosomes) and three non-SMC subunits and plays a major role in mitotic chromosome condensation. Condensin also acts in interphase and is required for DNA repair and replication checkpoint control. We attempted to study the function of the condensin in greater
Ee Sin, Chen +2 more
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Cancer Medicine, Volume 15, Issue 1, January 2026.ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo +2 more
wiley +1 more source
Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling [PDF]
Open Biology, 2015 SMC proteins are essential components of three protein complexes that are important for chromosome structure and function. The cohesin complex holds replicated sister chromatids together, whereas the condensin complex has an essential role in mitotic ...
Helena Barysz +6 more
doaj +1 more source