Results 81 to 90 of about 10,706 (194)
Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes [PDF]
Journal of Cell Science, 2007 The assembly of mitotic chromosomes is controlled by condensin complexes. In vertebrates, condensin I binds to chromatin in prometaphase, confers rigidity to chromosomes and enables the release of cohesin complexes from chromosome arms, whereas condensin II associates with chromosomes in prophase and promotes their condensation.
Lipp, J. +3 more
openaire +3 more sources
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.ABSTRACT Background Skeletal muscle atrophy is a common condition caused by numerous factors, such as aging (termed sarcopenia), disease (e.g., cancer cachexia) or specific medications (such as glucocorticoids). There is no FDA‐approved drug for treating skeletal muscle atrophy.
Eun‐Jin Park +9 more
wiley +1 more source
Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction [PDF]
, 2018 SummaryWhen human cells enter mitosis, chromosomes undergo substantial changes in their organisation to resolve sister chromatids and compact chromosomes.
Eykelenboom, John K +7 more
core +2 more sources
Tumour Cell Size Control and Its Impact on Tumour Cell Function
Cell Proliferation, Volume 58, Issue 12, December 2025.The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley +1 more source
Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells. [PDF]
PLoS Genetics, 2017 LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition.
Jacqueline R Ward +9 more
doaj +1 more source
Condensins: Organizing and Segregating the Genome [PDF]
Current Biology, 2005 Condensins are multi-subunit protein complexes that play a central role in mitotic chromosome assembly and segregation. The complexes contain 'structural maintenance of chromosomes' (SMC) ATPase subunits, and induce DNA supercoiling and looping in an ATP-hydrolysis-dependent manner in vitro.
openaire +2 more sources
New Phytologist, Volume 248, Issue 6, Page 2833-2849, December 2025.Summary Target of rapamycin (TOR) kinase is the hub of a eukaryotic master signaling network that integrates nutritional and hormonal signals into cellular activities. Most studies on TOR in plants have focused on seedlings, where TOR is most responsive to light and sucrose.
Brendan M. O'Leary +5 more
wiley +1 more source
Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation
eLife, 2017 Mitotic chromosome assembly remains a big mystery in biology. Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic chromatin remains unknown.
Ewa Piskadlo +2 more
doaj +1 more source
Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing [PDF]
Open Biology, 2011 Condensin is required for chromosome dynamics and diverse DNA metabolism. How condensin works, however, is not well understood. Condensin contains two structural maintenance of chromosomes (SMC) subunits with the terminal globular domains connected to ...
Yuko Akai +10 more
doaj +1 more source
SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? [PDF]
, 1999 The assembly of mitotic chromosomes is a fundamental cellular event that ensures the faithful segregation of genetic information during cell division. It involves two processes that are, in principle, mechanistically distinct.
Hirano, T.
core +1 more source