Marine Drugs, 2013 Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools ...
Rolf Boelens +4 more
doaj +1 more source
Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization [PDF]
, 2011 alpha-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans ...
Anton A. Grishin +10 more
core +1 more source
Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp.
Marine Drugs, 2016 Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe +9 more
doaj +1 more source
Insect-selective spider toxins targeting voltage-gated sodium channels [PDF]
, 2007 The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate Nav channel gating.
Nicholson, GM
core +1 more source
Venomics as a Drug Discovery Platform: Identifying Conopeptides with Pharmacological Activity [PDF]
, 2020 Cone snail venom is a mixture of disulfide-constrained peptides (conotoxins), hormone-like peptides, and proteins that have been ‘weaponized’ for predation and defense.
Grandal, Meghan Kathleen
core +1 more source
Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief [PDF]
, 2016 INTRODUCTION: Chronic pain is a massive clinical problem. We discuss the potential of subtype selective sodium channel blockers that may provide analgesia with limited side effects.
Emery, EC, Luiz, AP, Wood, JN
core +1 more source
Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery
British Journal of Pharmacology, Volume 182, Issue 16, Page 3691-3694, August 2025.
Christian W. Gruber +71 more
wiley +1 more source
Reconstructing the Origins of a Neuropeptide Signaling System Using the Accelerated Evolution of Biodiverse Cone Snail Venoms [PDF]
, 2021 Thomas Lund Koch +8 more
openalex +1 more source
Characterization of the
BMC Genomics, 2011 Background The venomous marine gastropods, cone snails (genus Conus), inject prey with a lethal cocktail of conopeptides, small cysteine-rich peptides, each with a high affinity for its molecular target, generally an ion channel, receptor or transporter.
Olivera Baldomero M +3 more
doaj +1 more source
Anopheline salivary protein genes and gene families: an evolutionary overview after the whole genome sequence of sixteen Anopheles species [PDF]
, 2017 Background: Mosquito saliva is a complex cocktail whose pharmacological properties play an essential role in blood feeding by counteracting host physiological response to tissue injury.
ARCA', Bruno +3 more
core +2 more sources