Results 141 to 150 of about 5,046 (227)

Less is more: Design of a highly stable disulfide-deleted mutant of analgesic cyclic alpha-conotoxin Vc1.1 [PDF]

, 2015
Cyclic alpha-conotoxin Vc1.1 (cVc1.1) is an orally active peptide with analgesic activity in rat models of neuropathic pain. It has two disulfide bonds, which can have three different connectivities, one of which is the native and active form.
Adams, D, Akcan, M, Berecki, G, Craik, D, Jia, X, Kaas, Q, Seymour, V, Yu, R   +7 more
core   +3 more sources

ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential

Marine Drugs, 2006
: Highly selective N-type voltage-gated calcium (CaV) channel inhibitors from cone snail venom (the ω-conotoxins) have emerged as a new class of therapeutics for the treatment of chronic and neuropathic pain.
Richard J. Lewis, Christina I. Schroeder
doaj   +1 more source

Identification of an Allosteric Binding Site in a G Protein-coupled Receptor Targeted by a Cone Snail Venom Peptide♦ [PDF]

, 2013

openalex   +1 more source

Avancées et nouvelles technologies en Toxinologie

, 2010
Collection Rencontres en Toxinologie ISSN 1760-6004 ; http://sfet.asso.fr/images/stories/SFET/pdf/Ebook-RT18-2010-signets-110322.pdfInternational ...
Barbier, Julien, Benoit, Evelyne, Marchot, P., Mattei, César, Servent, Denis   +4 more
core  

Stabilization of a-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization [PDF]

, 2011
a-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, including
Adams, DJ, Alvarmo, C, Clark, R, Craik, D, Daly, N, Grishin, A, Gunasekera, S, Lovelace, E, Nevin, S   +8 more
core  

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads [PDF]

, 2021
Iris Bea L. Ramiro, Walden E. Bjørn‐Yoshimoto, Julita S. Imperial, Joanna Gajewiak, Maren Watkins, Dylan Taylor, William Resager, Beatrix Ueberheide, Hans Bräuner‐Osborne, Frank G. Whitby, Christopher P. Hill, Laurent Martin, Amol Patwardhan, Gisela P. Concepción, Baldomero M. Olivera, Helena Safavi‐Hemami   +15 more
openalex   +1 more source

Phylogenetic Diversity and Venom Gland Transcriptomics of Palauan Cone Snails ( Conidae ) [PDF]

Hudson Judge, Ho Yan Yeung, Bailey W. Miller, Zhenjian Lin, Louis R. Barrows, Patrick L. Colin, Eric Schmidt, Helena Safavi-­Hemami, Thomas Lund Koch   +8 more
openalex   +1 more source

Y-aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic a-conotoxins [PDF]

, 2012
Background: A class of analgesic a-conotoxins potently inhibits N-type calcium channels. Results: The activity of a-conotoxins Vc1.1 and RgIA was reduced following knockdown of GABAB receptor expression in sensory neurons and can be reconstituted in ...
Adams, DJ, Berecki, G, Cuny, H, de Faoite, A, Huynh, T, Yasuda, T   +5 more
core  

Decision letter: Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

, 2018

openalex   +1 more source

Modulation of Conotoxin Structure and Function Is Achieved through a Multienzyme Complex in the Venom Glands of Cone Snails [PDF]

, 2012
Helena Safavi‐Hemami, Dhana G. Gorasia, Andrew M. Steiner, Nicholas A. Williamson, John A. Karas, Joanna Gajewiak, Baldomero M. Olivera, Grzegorz Bułaj, Anthony W. Purcell   +8 more
openalex   +1 more source