Results 121 to 130 of about 1,336 (154)
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Structural and biosynthetic properties of peptides in cone snail venoms
Peptides, 1995Venoms of the predatory cone snails Conus textile, Conus striatus, and Conus magus were subjected to comprehensive analysis of peptide content. With the fish-eating cone snails C. magus and C. striatus, the most abundant venom peptides were of > 30-50 residues, whereas the predominant peptides in the venom of the mollusc-eating snail, C.
R, Newcomb, S, Gaur, J R, Bell, L, Cruz
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Pharmacology of predatory and defensive venom peptides in cone snails
Molecular BioSystems, 2017Abstract Cone snails are predatory gastropods whose neurotoxic venom peptides (conotoxins) have been extensively studied for pharmacological probes, venom evolution mechanisms and potential therapeutics. Conotoxins have a wide range of structural and functional classes that continue to undergo accelerated evolution that underlies the ...
Jutty Rajan Prashanth +2 more
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Intraspecific variation in the venom of the vermivorous cone snail Conus vexillum
Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 2011A combination of proteomic and biochemical assays was used to examine variations in the venom of Conus vexillum taken from two locations (Hurgada and Sharm El-Shaikh) in the Red Sea, Egypt. Using MALDI/TOF-MS, a remarkable degree of intra-species variation between venom samples from both locations was identified.
Mohamed A Abdel-Rahman +2 more
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Phyla Molluska: The Venom Apparatus of Cone Snails
2015Predatory marine gastropods of the genus Conus comprise similar to 700 species that have evolved a highly specialized envenomation apparatus. This recently evolved genus has developed potent venoms separately for prey capture and defense. Both strategies utilize a complex but different cocktail of venom peptides that is injected through a hollow ...
Dutertre, Sebastien +2 more
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Cone Snail Venomics: From Novel Biology to Novel Therapeutics
Future Medicinal Chemistry, 2014Peptide neurotoxins from cone snails called conotoxins are renowned for their therapeutic potential to treat pain and several neurodegenerative diseases. Inefficient assay-guided discovery methods have been replaced by high-throughput bioassays integrated with advanced MS and next-generation sequencing, ushering in the era of 'venomics'. In this review,
Prashanth, Jutty Rajan +5 more
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Analysis of a cone snail's killer cocktail – The milked venom of Conus geographus [PDF]
Toxicon, 2012 "Snails can kill" is a statement that receives much disbelief. Yet the venom from Conus geographus, as delivered by a disposable hypodermic-like needle, has indeed killed many unsuspecting human victims. Our understanding of their milked venom the essence of these fatalities, is in itself non-existent.
Jon-Paul Bingham, Margaret R Baker
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Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis [PDF]
Marine Drugs, 2019 Individual variation in animal venom has been linked to geographical location, feeding habit, season, size, and gender. Uniquely, cone snails possess the remarkable ability to change venom composition in response to predatory or defensive stimuli. To date, correlations between the venom gland transcriptome and proteome within and between individual ...
Ai-Hua Jin +2 more
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Cone snail milked venom dynamics – A quantitative study of Conus purpurascens [PDF]
Toxicon, 2012 Milked venom from cone snails represent a novel biological resource with a proven track record for drug discovery. To strengthen this correlation, we undertook a chromatographic and mass spectrometric study of individual milked venoms from Conus purpurascens.
Margaret R Baker, Jon-Paul Bingham
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PPIase is associated with the diversity of conotoxins from cone snail venom glands
Biochimie, 2015Cone snails are incredibly rich sources of bioactive conopeptides with potential for use in neuroscience research and novel drug development. In order to investigate the synthesis of diversified conopeptides in venom glands, the proteome and peptidome profiles of conus venom were analyzed using HPLC and mass spectrometry.
Yuanyuan Qiang +2 more
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Neurotoxins of Cone Snail Venoms
2002Cone snails are predatory marine mollusks that rely on their venom components to immobilize and capture fish, worms, or other mollusks. Cones employ a number of prey-hunting strategies, ultimately involving the injection of venom through a hollow, harpoon-like, modified-tooth structure (1).
Robert Newcomb, George Miljanich
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