Results 111 to 120 of about 15,545 (229)

Adipocyte‐Derived Palmitic Acid Promotes Breast Cancer Malignancy via ZDHHC15‐Mediated S‐Palmitoylation of PPARγ

open access: yesCancer Science, EarlyView.
Adipocyte‐derived palmitic acid induces ZDHHC15‐mediated PPARγ S‐palmitoylation at Cys159, triggering its proteasomal degradation and promoting breast cancer malignancy with rosiglitazone resistance. Inhibition of PPARγ S‐palmitoylation by 2‐bromopalmitate suppresses breast cancer progression and synergistically enhances rosiglitazone efficacy ...
Geon Ho Moon   +6 more
wiley   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

open access: yesCell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu   +7 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

open access: yesCell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao   +7 more
wiley   +1 more source

Bioconversion of linoleic acid into conjugated linoleic acid by lactic

open access: yes, 2011
Conjugated linoleic acids (CLA) are a mixture of positional and geometric isomers of linoleic acid (cis-9, cis-12 octadecadienoic acid) with conjugated double bounds. Their principal dietary sources include ruminant and dairy fats, and CLA are shown to possess health beneficial effects on human health.
Gursoy, O, Yilmaz, Y, Ozel, S, Con, AH
openaire   +2 more sources

Comparative Study of Laboratory Diets for Piophila casei: Beneficial Effects of Infant Formula Supplementation

open access: yesEntomologia Experimentalis et Applicata, EarlyView.
The infant formula‐based diet (F), the whole powder milk diet (P), and dry‐cured ham (H) were evaluated for rearing Piophila casei. H accelerated development, promoted earlier reproduction, and achieved the highest demographic performance but showed practical limitations linked to substrate deterioration. F enhanced larval survival and adult longevity,
Diletta Missere   +3 more
wiley   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

open access: yesThe FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo   +4 more
wiley   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

open access: yesThe FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah   +5 more
wiley   +1 more source

A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet

open access: yesThe FEBS Journal, EarlyView.
C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr   +4 more
wiley   +1 more source

Synergistic enhancement SPF from annatto seed oil and alkaline extracts in association with organic UV filters

open access: yesInternational Journal of Cosmetic Science, EarlyView.
An SPF formulation incorporating Bixa orellana seed extracts and oils showed enhanced UV protection, highlighting the potential of natural bioactive compounds as effective boosters in photoprotective cosmetic products. Abstract Objective This study investigated the antioxidant activity of oil and alkaline aqueous extracts obtained from Bixa orellana ...
Ister Cordeiro Mariotini   +8 more
wiley   +1 more source

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