Results 111 to 120 of about 570,681 (325)

Genomic Characterization of a Clinical NDM-1-Producing Klebsiella michiganensis from Brazil

Microorganisms
Public health faces daily challenges due to increasing reports of pathogenic microorganisms with new antimicrobial resistance. Klebsiella michiganensis, an emerging pathogen, poses difficulty in its identification using conventional techniques.
Amanda Yaeko Yamada, Andreia Rodrigues de Souza, Amanda Maria de Jesus Bertani, Karoline Rodrigues Campos, Claudio Tavares Sacchi, Denise Brandão de Assis, Enéas de Carvalho, Elizabeth Harummyy Takagi, Marcos Paulo Vieira Cunha, Monique Ribeiro Tiba-Casas, Carlos Henrique Camargo   +10 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Study of gold nanoparticles’ preparation through ultrasonic spray pyrolysis and lyophilisation for possible use as markers in LFIA tests

Nanotechnology Reviews, 2021
Jelen Žiga, Majerič Peter, Zadravec Matej, Anžel Ivan, Rakuša Martin, Rudolf Rebeka   +5 more
doaj   +1 more source

Conjugation on reddening sequences and conjugation difference

Journal of Algebra
We describe the conjugation of the reddening sequence according to the formula of $c$-vectors with respect to changing the initial seed. As applications, we extend the Rotation Lemma, the Target before Source Theorem, and the mutation invariant property of the existence of reddening sequences to totally sign-skew-symmetric cluster algebras. Furthermore,
Siyang Liu, Jie Pan
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Prevalence of the bla CTX-M group and their transferability in resistant clinical isolates of Salmonella serogroups from several hospitals of Tehran

Iranian Journal of Microbiology, 2015
Background and Objectives: Salmonella is an important food-borne pathogen in humans. Strains of Salmonella spp. That producing extended-spectrum β-Lactamases have become a concern in medicine regarding both antimicrobial treatment and infection control ...
Kobra Salimian-Rizi, Shahin Najar Peerayeh, Bita Bakhshi, Mohammad Rahbar   +3 more
doaj  

Toward ⁶⁸Ga and ⁶⁴Cu Positron Emission Tomography Probes: Is H₂dedpa-N,N′-pram the Missing Link for dedpa Conjugation? [PDF]

, 2023
Celia Pena-Bonhome, Desiree Fiaccabrino, Tamara Rama, Daniel Fernández-Pavón, Lily Southcott, Zhengxing Zhang, Kuo‐Shyan Lin, A. De Blas, Brian O. Patrick, Paul Schaffer, Chris Orvig, Marı́a de Guadalupe Jaraquemada-Peláez, T. Rodríguez-Blas   +12 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

FACTORS DETERMINING CONJUGATION IN PARAMECIUM AURELIA I. THE CYCLICAL FACTOR: THE RECENCY OF NUCLEAR REORGANIZATION [PDF]

, 1936
T. M. Sonneborn
openalex   +1 more source