Results 21 to 30 of about 337,623 (298)

Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine

bioRxiv, 2020
Autophagy is a fundamental catabolic process essential for development, homeostasis and proper immune function 1. During autophagy, a cascade of ATG proteins target intracellular cargoes for lysosomal degradation and recycling 2.
J. Durgan, A. H. Lystad, K. Sloan, S. Carlsson, Michael I. Wilson, E. Marcassa, Rachel Ulferts, J. Webster, A. Lopez-Clavijo, M. Wakelam, R. Beale, A. Simonsen, David Oxley, O. Florey   +13 more
semanticscholar   +1 more source

Reducing-End Functionalization of 2,5-Anhydro-d-mannofuranose-Linked Chitooligosaccharides by Dioxyamine: Synthesis and Characterization

Molecules, 2020
The nitrous acid depolymerization of chitosan enables the synthesis of singular chitosan oligosaccharides (COS) since their reducing-end unit is composed of 2,5-anhydro-d-mannofuranose (amf).
Maxence Coudurier, Jimmy Faivre, Agnès Crépet, Catherine Ladavière, Thierry Delair, Christophe Schatz, Stéphane Trombotto   +6 more
doaj   +1 more source

Intermolecular cascaded π-conjugation channels for electron delivery powering CO2 photoreduction

Nature Communications, 2020
Photoreduction of CO2 to fuels offers a promising strategy for managing the global carbon balance using renewable solar energy. But the decisive process of oriented photogenerated electron delivery presents a considerable challenge.
Shengyao Wang, Xiao Hai, X. Ding, Shangbin Jin, Yonggang Xiang, Pei Wang, B. Jiang, Fumihiko Ichihara, M. Oshikiri, Xianguang Meng, Yunxiang Li, W. Matsuda, Jun Ma, S. Seki, Xuepeng Wang, Hao Huang, Y. Wada, Hao Chen, Jinhua Ye   +18 more
semanticscholar   +1 more source

Natural Occurring and Engineered Enzymes for Peptide Ligation and Cyclization

Frontiers in Chemistry, 2019
The renaissance of peptides as prospective therapeutics has fostered the development of novel strategies for their synthesis and modification. In this context, besides the development of new chemical peptide ligation approaches, especially the use of ...
Timo Nuijens, Ana Toplak, Marcel Schmidt, Antonio Ricci, Walter Cabri, Walter Cabri   +5 more
doaj   +1 more source

Correlation between Exogenous Compounds and the Horizontal Transfer of Plasmid-Borne Antibiotic Resistance Genes

Microorganisms, 2020
The global spread of antibiotic resistance has posed a serious threat to public healthcare and undermined decades of progress made in the fight against bacterial infections.
Yuan Liu, Ziwen Tong, Jingru Shi, Yuqian Jia, Kangni Yang, Zhiqiang Wang   +5 more
doaj   +1 more source

The Type IV Secretion System of ICEAfe1: Formation of a Conjugative Pilus in Acidithiobacillus ferrooxidans

Frontiers in Microbiology, 2019
The dispersal of mobile genetic elements and their gene cargo relies on type IV secretion systems (T4SS). In this work the ICEAfe1 Tra-type T4SS nanomachine, encoded in the publicly available genome of Acidithiobacillus ferrooxidans ATCC 23270TY, was ...
Rodrigo Flores-Ríos, Rodrigo Flores-Ríos, Ana Moya-Beltrán, Ana Moya-Beltrán, Claudia Pareja-Barrueto, Mauricio Arenas-Salinas, Sebastián Valenzuela, Omar Orellana, Raquel Quatrini, Raquel Quatrini   +9 more
doaj   +1 more source

Direct Conjugation of Resveratrol on Hydrophilic Gold Nanoparticles: Structural and Cytotoxic Studies for Biomedical Applications

Nanomaterials, 2020
Strongly hydrophilic gold nanoparticles (AuNPs), functionalized with citrate and L-cysteine, were synthetized and used as Resveratrol (RSV) vehicle to improve its bioavailability.
Iole Venditti, Giovanna Iucci, Ilaria Fratoddi, Manuela Cipolletti, Emiliano Montalesi, Maria Marino, Valeria Secchi, Chiara Battocchio   +7 more
doaj   +1 more source

Characterizing conjugative plasmids from an antibiotic-resistant dataset for use as broad-host delivery vectors

Frontiers in Microbiology, 2023
Human microbiome engineering is increasingly proposed as a way to modulate health outcomes. However, one of the current limitations to engineering microbial communities in situ is delivery of a genetic payload for introducing or modifying genes.
Héctor G. Loyola Irizarry, Ilana L. Brito   +1 more
doaj   +1 more source

A purple odyssey: synthesis and structure of 3-amino-4-hydroxy-6-oxocyclohexa-2,4-dien-1-iminium chloride monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the cation of the title hydrated molecular salt, C6H7N2O2+·Cl−·H2O, the six-membered ring shows unequal bond lengths consistent with delocalization of electrons over two separate 6π systems with single bonds between them.
M. John Plater, William T. A. Harrison
doaj   +1 more source

Differential Requirement for the Cell Wall Integrity Sensor Wsc1p in Diploids Versus Haploids

Journal of Fungi, 2021
The primary role of the Cell Wall Integrity Pathway (CWI) in Saccharomyces cerevisiae is monitoring the state of the cell wall in response to general life cycle stresses (growth and mating) and imposed stresses (temperature changes and chemicals). Of the
Allison E. Hall, Miriam Lisci, Mark D. Rose   +2 more
doaj   +1 more source