Results 61 to 70 of about 549,520 (273)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Why does a metal-superconductor junction have a resistance? [PDF]

, 2000
This is a tutorial article based on a lecture delivered in June 1999 at the NATO Advanced Study Institute in Ankara. The phenomenon of Andreev reflection is introduced as the electronic analogue of optical phase-conjugation.
AA Abrikosov, AF Andreev, AF Andreev, BI Stepanov, BI Stepanov, CWJ Beenakker, CWJ Beenakker, DM Pepper, E Toyoda, GE Blonder, H Courtois, H Houten van, IO Kulik, IO Kulik, J Feinberg, J. C, JCJ Paasschens, JP Woerdman, SN Artemenko, Y Takane, YV Nazarov   +20 more
core   +3 more sources

Amino-Acid-Conjugated Natural Compounds: Aims, Designs and Results

Molecules, 2022
Protein is one of the essential macronutrients required by all living things. The breakdown of protein produces monomers known as amino acids. The concept of conjugating natural compounds with amino acids for therapeutic applications emerged from the ...
Hanggara Arifian, Rani Maharani, Sandra Megantara, Amirah Mohd Gazzali, Muchtaridi Muchtaridi   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The fine implicative structure of European Portuguese conjugation

Isogloss, 2021
Recent literature has highlighted the extent to which inflectional paradigms are organised into systems of implications allowing speakers to make full use of the inflection system on the basis of exposure to only a few forms of each word.
Sacha Beniamine, Olivier Bonami, Ana R. Luís   +2 more
doaj  

The Lactococcus lactis Pan-Plasmidome

Frontiers in Microbiology, 2019
Plasmids are autonomous, self-replicating, extrachromosomal genetic elements that are typically not essential for growth of their host. They may encode metabolic capabilities, which promote the maintenance of these genetic elements, and may allow ...
Philip Kelleher, Philip Kelleher, Jennifer Mahony, Jennifer Mahony, Francesca Bottacini, Gabriele A. Lugli, Marco Ventura, Douwe van Sinderen, Douwe van Sinderen   +8 more
doaj   +1 more source

IncHI1 plasmids are epidemic vectors that mediate transmission of tet(X4) in Escherichia coli isolated from China

Frontiers in Microbiology, 2023
IntroductionThis study aimed to investigate the genetic factors promoting widespread Q6 dissemination of tet(X4) between Escherichia coli and to characterize the genetic contexts of tet(X4).MethodsWe isolated E.
Yan Zhang, Yan Zhang, Jie Zhang, Jie Zhang, Ping Cai, Ping Cai, Yang Lu, Yang Lu, Ruan-Yang Sun, Ruan-Yang Sun, Meng-Tao Cao, Meng-Tao Cao, Xiao-Li Xu, Mark A. Webber, Hong-Xia Jiang, Hong-Xia Jiang   +15 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Successful Transfer of a Model T-DNA Plasmid to E. coli Revealed Its Dependence on Recipient RecA and the Preference of VirD2 Relaxase for Eukaryotes Rather Than Bacteria as Recipients

Frontiers in Microbiology, 2018
In Agrobacterium-mediated transformation (AMT) of plants, a single-strand (ss) T-DNA covalently linked with a VirD2 protein moves through a bacterial type IV secretion channel called VirB/D4.
Yuta Ohmine, Kazuya Kiyokawa, Kazuya Yunoki, Shinji Yamamoto, Kazuki Moriguchi, Katsunori Suzuki   +5 more
doaj   +1 more source

GENETIC ASPECTS OF INDIRECT HYPERBILIRUBINAEMIA IN NEWBORNS

Slovenska pediatrija, 2022
Indirect hyperbilirubinaemia is a common finding in the neonatal period. There are numerous causes of neonatal indirect hyperbilirubinemia, from excessive bilirubin production, impaired hepatic bilirubin uptake or bilirubin conjugation and increased ...
Katja Jarc Georgiev, Manca Velkavrh
doaj   +1 more source