Results 201 to 210 of about 10,862 (262)

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Assessing São Paulo's public transport efficiency and coverage through data-driven modeling of autonomous vehicle and vehicle-as-a-service integration. [PDF]

Sci Rep
Antonio LHL, Terenciani SJC, Eler DM, Filho GPR, Junior LAP, De Grande RE, Meneguette RI.   +6 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Dataset of electric autonomous dial-a-ride instances with local energy communities and electricity tariffs. [PDF]

Data Brief
Almeida J, Limmer S, Soares J, Bresich M, Raidl G, Vale Z.   +5 more
europepmc   +1 more source

Unified Semantic Reasoning and Planning for Autonomous Driving. [PDF]

Sensors (Basel)
An YC, Choi JH, Pyo JW, Bae SH, Kuc TY.
europepmc   +1 more source

An End-to-End Trajectory Prediction Method for Unmanned Ground Vehicles via Multimodal Fusion. [PDF]

Sensors (Basel)
Li Y, Tian E, Yang F, Han H, Zhang X.
europepmc   +1 more source

Trajectory Prediction-Enabled Self-Decision-Making for Autonomous Cleaning Robots in Semi-Structured Dynamic Campus Environments. [PDF]

Sensors (Basel)
Peng J, Zhu Z, Fan Q, Xia R, Yin Z.
europepmc   +1 more source

Securing Data in Vehicles: Privacy-Preserving Frameworks for Dynamic CAV Environments. [PDF]

Sensors (Basel)
Hammedi R, Brown DJ, Kaiwartya O, Gaur P.   +3 more
europepmc   +1 more source

Connectivity-Aware Model Predictive Control for Swarms of Dynamically Constrained Vehicles Engaged in Multi-Target Persistent Observation

Derder Y, Erünsal IK, Martinoli A.
europepmc   +1 more source