A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function [PDF]
Frontiers in Physiology, 2019 Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Gaia Ziraldo +18 more
doaj +3 more sources
In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors [PDF]
Scientific Reports, 2017 We have previously shown that in vitro transduction with bovine adeno–associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin–deficient mice that are models DFNB1 ...
Giulia Crispino +7 more
doaj +2 more sources
Expression of connexins and pannexins in diseased human liver
EXCLI Journal : Experimental and Clinical Sciences, 2022 Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction activity is crucial for the maintenance of hepatic homeostasis, while connexin hemichannels ...
Kaat Leroy +8 more
doaj +3 more sources
Role of gap junctions and connexin 43 in cancerogenesis and tumor metastasis [PDF]
Medicinski Podmladak, 2022 Gap junctions are intercellular connections that enable direct communication between neighboring cells. They are important in tissue homeostasis, cell growth, and differentiation.
Savić Ivana +2 more
doaj +1 more source
Connexin communication compartments and wound repair in epithelial tissue [PDF]
, 2018 Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they ...
Chanson, Marc +4 more
core +13 more sources
Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. [PDF]
PLoS ONE, 2011 Emerging evidence suggests that connexin mediated gap junctional intercellular communication contributes to many aspects of bone biology including bone development, maintenance of bone homeostasis and responsiveness of bone cells to diverse extracellular
Yue Zhang +8 more
doaj +1 more source
Frontiers in Oncology, 2020 Cetuximab is a monoclonal antibody that acts as an anti-epidermal growth factor receptor (EGFR) agent. Cetuximab inhibits the phosphorylation and activation of EGFR and blocks downstream signal pathways of EGF/EGFR, including Ras-Raf-MAPK and PI3K-Akt ...
Yijia Wang +7 more
doaj +1 more source
Sex- and Age-Related Changes in Connexin 43 Expression in Normal Rat Bladder [PDF]
International Neurourology Journal, 2011 Purpose Gap junctions are intercellular channels to facilitate electrical and metabolic communication between adjacent cells. Connexin 43 is the most predominant type of connexin expressed on rat detrusor muscle cells.
Sung Ho Song +5 more
doaj +1 more source
Mutations of CX46/CX50 and Cataract Development
Frontiers in Molecular Biosciences, 2022 Cataract is a common disease in the aging population. Gap junction has been considered a central component in maintaining homeostasis for preventing cataract formation. Gap junction channels consist of connexin proteins with more than 20 members.
Yumeng Shi, Xinbo Li, Jin Yang
doaj +1 more source
Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26
Biology, 2021 Epithelial tissue responds rapidly to environmental triggers and is constantly renewed. This tissue is also highly accessible for therapeutic targeting.
Laura Garcia-Vega +3 more
doaj +1 more source