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Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26 [PDF]
Biology, 2021 Epithelial tissue responds rapidly to environmental triggers and is constantly renewed. This tissue is also highly accessible for therapeutic targeting.
Laura Garcia-Vega +3 more
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Frontiers in Oncology, 2020 Cetuximab is a monoclonal antibody that acts as an anti-epidermal growth factor receptor (EGFR) agent. Cetuximab inhibits the phosphorylation and activation of EGFR and blocks downstream signal pathways of EGF/EGFR, including Ras-Raf-MAPK and PI3K-Akt ...
Yijia Wang +7 more
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Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate. [PDF]
PLoS ONEGap junction intercellular communication (GJIC) between two adjacent cells involves direct exchange of cytosolic ions and small molecules via connexin gap junction channels (GJCs).
Pia Lavriha +7 more
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Role of gap junctions and connexin 43 in cancerogenesis and tumor metastasis [PDF]
Medicinski Podmladak, 2022 Gap junctions are intercellular connections that enable direct communication between neighboring cells. They are important in tissue homeostasis, cell growth, and differentiation.
Savić Ivana +2 more
doaj +1 more source
Targeting Connexin 43 in Retinal Astrocytes Promotes Neuronal Survival in Glaucomatous Injury. [PDF]
GliaMain Points Astrocytes play an important role in glaucoma. These cells express Cx43 which can form gap junctions and hemichannels. This study shows Cx43 deletion in astrocytes provides neuroprotection in glaucoma, possibly through hemichannel activation.
Batsuuri K +4 more
europepmc +2 more sources
Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. [PDF]
PLoS ONE, 2011 Emerging evidence suggests that connexin mediated gap junctional intercellular communication contributes to many aspects of bone biology including bone development, maintenance of bone homeostasis and responsiveness of bone cells to diverse extracellular
Yue Zhang +8 more
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Cardiology Research and Practice, 2012 Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called “connexins.” In this paper, we discuss current knowledge about ...
Josephine A. Wright +2 more
openaire +3 more sources
Cold Spring Harbor Perspectives in Biology, 2017 Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system, cochlea, and skin, as well as cancer and pleiotropic syndromes such as oculodentodigital dysplasia ...
Delmar, Mario +5 more
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Mutations of CX46/CX50 and Cataract Development
Frontiers in Molecular Biosciences, 2022 Cataract is a common disease in the aging population. Gap junction has been considered a central component in maintaining homeostasis for preventing cataract formation. Gap junction channels consist of connexin proteins with more than 20 members.
Yumeng Shi, Xinbo Li, Jin Yang
doaj +1 more source
Sex- and Age-Related Changes in Connexin 43 Expression in Normal Rat Bladder [PDF]
International Neurourology Journal, 2011 Purpose Gap junctions are intercellular channels to facilitate electrical and metabolic communication between adjacent cells. Connexin 43 is the most predominant type of connexin expressed on rat detrusor muscle cells.
Sung Ho Song +5 more
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