Results 91 to 100 of about 26,063 (225)
AntioxidantsPlant extracts are rich in various bioactive compounds, such as polyphenols, flavonoids, tannins, terpenoids, phenolic acids, saponins, alkaloids, and polysaccharides.
Gintarė Jančiukė +4 more
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Two novel GJA1 variants in oculodentodigital dysplasia
Molecular Genetics & Genomic Medicine, 2019 Background Oculodentodigital dysplasia (ODDD) is a rare disorder with pleiotropic effects involving multiple body systems, caused by mutations in the gap junction protein alpha 1 (GJA1) gene. GJA1 gene encodes a polytopic connexin membrane protein, Cx43,
Nikolai P. Pace +6 more
doaj +1 more source
Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment [PDF]
, 2017 Michela Pecoraro +6 more
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A, three‐dimensional representation of cardiac intercalated disk, reduced to a 100‐partition, computationally efficient network representation. B, ion dynamics within intercalated disk extracellular cleft space. C, rapid pacing leads to localized conduction block in tissue with regions of perturbed intercalated disk (ID ...
Nicolae Moise +6 more
wiley +1 more source
Targeting connexin 43 in diabetic wound healing
Journal of Postgraduate Medicine, 2009 The unknown mechanisms of impaired tissue repair in diabetes mellitus are making this disease a serious clinical problem for the physicians worldwide. The lacuna in the knowledge of the etiology of diabetic wounds necessitates more focused research in order to develop new targeting tools with higher efficacy for their ...
Bajpai, S +4 more
openaire +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones +2 more
wiley +1 more source
CONNEXIN 43 HEMICHANNELS CAN DRIVE THE GLIOBLASTOMA SPREADING
European Journal of HistochemistryGlioblastoma (GBM) is the most common and aggressive primary tumor of the central nervous system (CNS) among high-grade gliomas (HGG). Patients with GBM often have a poor prognosis.
doaj +1 more source
Effects of Connexin 43 Inhibition in an Ovalbumin-induced Mouse Model of Asthma
Iranian Journal of Allergy, Asthma and Immunology, 2018 Connexion 43 (Cx43), a gap junction protein, is expressed abundantly in the airway and has been implicated in the pathogenesis of asthma. However, the effects of blocking Cx43 in asthma remain unclear.
Jian-Qiang Huang +5 more
doaj
Connexin 43 contributes to phenotypic robustness of the mouse skull [PDF]
, 2021 Elizabeth Jewlal +3 more
openalex +1 more source
Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin
The Journal of Physiology, EarlyView.Abstract figure legend DOX differentially impacts cardiac electrophysiology based on sex and age. Sex differences were primarily observed among younger hearts, where action potential duration (APD) prolongation was observed in females, but not in males. Created using BioRender. George, S. (2026) https://BioRender.com/wresf1k Abstract Acute doxorubicin (
Sharon A. George +5 more
wiley +1 more source