Results 141 to 150 of about 75,295 (332)

Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors [PDF]

, 2010
Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (
Cursons, Raymond T., Jacobson, Gregory M., Mason, Jonathan P., Melin, Sofia M., Sleigh, James W., Steyn-Ross, D. Alistair, Steyn-Ross, Moira L., Voss, Logan J.   +7 more
core   +2 more sources

Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration

OncoTarget, 2015
Impaired expression of connexins, the gap junction subunits that facilitate direct cell-cell communication, have been implicated in prostate cancer growth.
Ao Zhang, M. Hitomi, Noah Bar-Shain, Z. Dalimov, L. Ellis, K. Velpula, G. Fraizer, R. Gourdie, J. Lathia   +8 more
semanticscholar   +1 more source

Dexrazoxane protects against doxorubicin‐induced cardiotoxicity in susceptible human living myocardial slices: A proof‐of‐concept study

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The increasing number of cancer survivors has caused growing concern over chemotherapy‐induced cardiotoxicity. This study aimed to investigate a novel human model of cardiotoxicity and explore cardioprotection. Experimental Approach Living myocardial slices (LMS) were obtained from explanted end‐stage heart failure ...
Jort S. A. van der Geest, Ilse R. Kelters, Bauke Arends, Willem B. van Ham, Ernest Diez Benavente, Thirza A. Lapré, Petra van der Kraak, Pim van der Harst, Arco J. Teske, Andreas Dendorfer, M. Mostafa Mokhles, Pieter A. Doevendans, Teun P. de Boer, Linda W. van Laake, Joost P. G. Sluijter, Vasco Sampaio‐Pinto   +15 more
wiley   +1 more source

Molecular cloning and characterization of a new member of the gap junction gene family, connexin-31 [PDF]

, 1991
A new member of the connexin gene family has been identified and designated rat connexin-31 (Cx31) based on its predicted molecular mass of 30,960 daltons. Cx31 is 270 amino acids long and is coded for by a single copy gene.
Hoh, Jan H., John, Scott A., Revel, Jean-Paul   +2 more
core  

Electrical coupling between ventricular myocytes and myofibroblasts in the infarcted mouse heart [PDF]

, 2017
Aims: Recent studies have demonstrated electrotonic coupling between scar tissue and the surrounding myocardium in cryoinjured hearts. However, the electrical dynamics occurring at the myocyte-nonmyocyte interface in the fibrotic heart remain ...
Conway, Simon J., Lin, Shien-Fong, Lu, Xiao-Long, Reuter, Sean P., Rubart, Michael, Soonpaa, Mark H., Tao, Wen   +6 more
core   +1 more source

Connexin43 Promotes the Invasion and Metastasis of Lung Squamous Cell Carcinoma via GJIC‐Dependent Ca2+/ERK Signaling Activation

Cancer Science, EarlyView.
Cx43 mediated GJIC‐dependent delivery of second messenger Ca2+ thus activating the ERK signaling pathway. Verapamil, effective effectively inhibits these pathways. ABSTRACT Lung squamous cell carcinoma (LUSC) is an extremely metastatic cancer with limited available treatment and poor outcomes.
Xiaocheng Mo, Jingchuan He, Xiaoju Shen, Changsheng Li, Xiaoxiang Mo, Kai Liang, Liangjun He, Tingting Li, Xiaoqin Pan, Sisi Cao, Naiquan Mao, Shangping Xing, Zhiquan Chen, Zhuo Luo, Jie Yang   +14 more
wiley   +1 more source

Molecular basis of gap junctional communication in the CNS of the leech Hirudo medicinalis [PDF]

, 2004
Gap junctions are intercellular channels that allow the passage of ions and small molecules between cells. In the nervous system, gap junctions mediate electrical coupling between neurons.
Bacon, Jonathan P, Davies, Jane A, Dykes, Iain M, Freeman, Fiona M   +3 more
core   +2 more sources

Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations

Journal of Neuroscience, 2015
An emergent concept in neurosciences consists in considering brain functions as the product of dynamic interactions between neurons and glial cells, particularly astrocytes.
L. Roux, A. Madar, M. Lacroix, Chenju Yi, K. Benchenane, C. Giaume   +5 more
semanticscholar   +1 more source

Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

Cell Proliferation, EarlyView.
ECH protects senescent oocytes by stabilising the cytoskeleton, restoring mitochondrial function, reducing oxidative stress and maintaining cellular homeostasis, primarily through the GJA1/SIRT1 signalling pathway. ABSTRACT As maternal age increases, the decline in oocyte quality emerges as a critical factor contributing to reduced reproductive ...
Liuqing Yang, Xinle Lai, Fangxuan Lin, Nan Shi, Xinya Xu, Heng Wang, Xiaotian Li, Dan Shen, Haimo Qian, Xin Jin, Jiayi Chen, Zhongwei Huang, Xing Duan, Qin Zhang   +13 more
wiley   +1 more source

Connexin the dots

The Journal of Cell Biology, 2002
New dyes developed by Guido Gaietta, Roger Tsien, Mark Ellisman (University of California at San Diego, La Jolla, CA), and colleagues allow efficient fluorescent and electron microscopy for studying the location, trafficking, assembly, and turnover of proteins and protein complexes.“We were interested in being able to go from light microscopy to the EM
openaire   +2 more sources