Results 11 to 20 of about 75,295 (332)
Connexin-mediated signaling in nonsensory cells is crucial for the development of sensory inner hair cells in the mouse cochlea [PDF]
Journal of Neuroscience, 2017 open9siMutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and humans.
Stuart L. Johnson +8 more
core +2 more sources
Connexin-43-dependent ATP release mediates macrophage activation during sepsis
eLife, 2019 Bacterial spillage into a sterile environment following intestinal hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically depends on macrophage activation by extracellular ATP-release and associated autocrine ...
Michel Dosch +7 more
doaj +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap ...
Pietro Enea Lazzerini +15 more
doaj +2 more sources
Connexin-dependent neuroglial networking as a new therapeutic target [PDF]
Frontiers in Cellular Neuroscience, 2017 Astrocytes and neurons dynamically interact during physiological processes, and it is now widely accepted that they are both organized in plastic and tightly regulated networks.
Christian C. Naus +5 more
core +6 more sources
A Human-Derived Monoclonal Antibody Targeting Extracellular Connexin Domain Selectively Modulates Hemichannel Function [PDF]
Frontiers in Physiology, 2019 Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations
Gaia Ziraldo +18 more
doaj +3 more sources
In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors [PDF]
Scientific Reports, 2017 We have previously shown that in vitro transduction with bovine adeno–associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin–deficient mice that are models DFNB1 ...
Giulia Crispino +7 more
doaj +2 more sources
Frontiers in Cellular Neuroscience, 2015 Hearing loss due to mutations in the connexin gene family which encodes gap junctional proteins is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) mutations are responsible for ~50% of nonsyndromic hearing loss, which is the
Jeffrey C Wingard, Hong-Bo eZhao
doaj +2 more sources
Hunting for connexin hemichannels [PDF]
FEBS Letters, 2014 Connexin hemichannels (connexons) are building blocks of gap junctions but also function as free unapposed channels, which has become an active field of research. Defining functions of hemichannels and their involvement in any biological event requires ruling out possible participation of other channels that share biophysical and regulatory properties,
Saez, Juan C., Leybaert, Luc
openaire +6 more sources
Recent advances in connexin gap junction biology
Faculty Reviews, 2022 Connexins are assembled into dodecamer intercellular channels, a collection of which is termed a gap junction, and their canonical function allowing direct exchange of ions and metabolites has been unequivocally established. When initially assembled into
P. Lampe, D. Laird
semanticscholar +1 more source
The Role of Connexin Hemichannels in Inflammatory Diseases
Biology, 2022 Simple Summary Connexin hemichannels are formed by connexin protein family members, and connect cytosol and extracellular milium. The function of connexin hemichannels cannot be readily distinguished from the gap junctions formed also by connexins, or ...
Bo Peng +4 more
semanticscholar +1 more source