Results 21 to 30 of about 75,295 (332)
Mechanisms Underlying Connexin Hemichannel Activation in Disease
International Journal of Molecular Sciences, 2021 Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their ...
Raf Van Campenhout +5 more
semanticscholar +1 more source
Connexins: synthesis, post-translational modifications, and trafficking in health and disease [PDF]
, 2018 Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs.
Aasen, Trond +5 more
core +13 more sources
Biomolecules & Biomedicine, 2020 The functions of androgen and connexin in the mammalian female reproductive system are suggested to be related. Previous research has shown that androgen affects connexin expression in the female reproductive system, altering its function.
Datu Agasi Mohd Kamal +2 more
doaj +1 more source
Connexins in the skeleton [PDF]
Seminars in Cell & Developmental Biology, 2016 Shaping of the skeleton (modeling) and its maintenance throughout life (remodeling) require coordinated activity among bone forming (osteoblasts) and resorbing cells (osteoclasts) and osteocytes (bone embedded cells). The gap junction protein connexin43 (Cx43) has emerged as a key modulator of skeletal growth and homeostasis. The skeletal developmental
Roberto Civitelli, Joseph P. Stains
openaire +3 more sources
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source
Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel
Science Advances, 2020 Cryo-EM structure of human connexin 31.3 hemichannel reveals the selective permeability mechanism. Connexin family proteins assemble into hexameric channels called hemichannels/connexons, which function as transmembrane channels or dock together to form ...
Hyuk-Joon Lee +7 more
semanticscholar +1 more source
Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses
mBio, 2020 Recent studies suggest that extracellular cGAMP can be taken up by macrophages to engage STING through several mechanisms. Our work demonstrates that connexin-dependent communication between epithelial cells and macrophages plays a significant role in ...
Geneviève Pépin +15 more
semanticscholar +1 more source
Folia Histochemica et Cytobiologica, 2008 The interaction of connexin 43 and E-cadherin may play an important role in carcinogenesis and malignant behaviour of tumours. In this study, we examined the relationship between connexin 43 and E-cadherin in human non-small cell lung cancers (NSCLC ...
En-Hua Wang +6 more
doaj +1 more source
Connexins and their channels in inflammation [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2016 Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury trigger, to clear out dead cells from damaged tissue and to initiate tissue regeneration.
Joost Willebrords +9 more
openaire +4 more sources
Connexins : substrates and regulators of autophagy [PDF]
, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
core +1 more source