Results 21 to 30 of about 64,299 (311)

Dynamic changes in connexin expression correlate with key events in the wound healing process. [PDF]

open access: yes, 2003
Wound healing is a complex process requiring communication for the precise co-ordination of different cell types. The role of extracellular communication through growth factors in the wound healing process has been extensively documented, but the role of
Becker, David L   +4 more
core   +1 more source

Connexins and Diabetes [PDF]

open access: yesCardiology Research and Practice, 2012
Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called “connexins.” In this paper, we discuss current knowledge about ...
Josephine A. Wright   +2 more
openaire   +3 more sources

Adenovirus-mediated delivery of bFGF small interfering RNA increases levels of connexin 43 in the glioma cell line, U251

open access: yesJournal of Experimental & Clinical Cancer Research, 2010
Background bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth.
Liu Hongsheng   +5 more
doaj   +1 more source

Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory [PDF]

open access: yes, 2016
Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ...
Albertini, Giulia   +5 more
core   +2 more sources

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro

open access: yesBMC Cardiovascular Disorders, 2006
Background Organ transplantation is presently often the only available option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from autologous skeletal myoblasts is a promising novel therapeutic strategy.
Kienast Yvonne   +9 more
doaj   +1 more source

Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]

open access: yes, 2006
Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Forge, A, Jagger, DJ
core   +1 more source

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system [PDF]

open access: yes, 2012
ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Bultynck, Geert   +7 more
core   +6 more sources

Connexin channels and phospholipids: association and modulation

open access: yesBMC Biology, 2009
Background For membrane proteins, lipids provide a structural framework and means to modulate function. Paired connexin hemichannels form the intercellular channels that compose gap junction plaques while unpaired hemichannels have regulated functions in
Harris Andrew L, Locke Darren
doaj   +1 more source

Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss

open access: yesExperimental and Molecular Medicine, 2020
Hearing loss: Disruption at the junction A decrease in the levels of connexin proteins at the junctions connecting cells in the inner-ear precedes age-related hearing loss (ARHL) in mice.
Shori Tajima   +3 more
doaj   +1 more source

Divergence between Hemichannel and Gap Junction Permeabilities of Connexin 30 and 26

open access: yesLife, 2023
Cx30 has been proposed to play physiological functions in the kidney and cochlea, and this has often been associated with its hemichannel role (deafness mutants frequently affecting hemichannels more than gap junctions), implicated in ATP release.
Ji Xu, Bruce J. Nicholson
doaj   +1 more source

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