Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]
, 2019 Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An +8 more
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The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes [PDF]
, 2014 In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct ...
Abudara, Verónica +8 more
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Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. [PDF]
PLoS ONE, 2013 Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis.
Travis P Barr +5 more
doaj +1 more source
Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice
Cells, 2022 In the lens, cell homeostasis and transparency are supported by intercellular communication facilitated by the channels formed of connexin46 (Cx46) and connexin50 (Cx50). Mutations of these connexins are linked to inherited cataracts.
Oscar Jara +3 more
doaj +1 more source
Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats [PDF]
, 2015 Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in ...
Choisy, Stéphanie C. +5 more
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Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study [PDF]
, 2019 Purpose Even with an optimal treatment protocol, the median survival of glioblastoma (GB) patients is only 12-15 months. Hence, there is need for novel effective therapies that improve survival outcomes.
Bonte, Ellen +11 more
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BMC Genomics, 2020 Background Based on an initial collecting of database sequences from the gap junction protein gene family (also called connexin genes) in a few teleosts, the naming of these sequences appeared variable. The reasons could be (i) that the structure in this
Svein-Ole Mikalsen +2 more
doaj +1 more source
Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors [PDF]
, 2010 Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (
Cursons, Raymond T. +7 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap ...
Pietro Enea Lazzerini +15 more
doaj +1 more source
Connexins : substrates and regulators of autophagy [PDF]
, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
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