Results 41 to 50 of about 64,299 (311)

The Amino Terminal Domain and Modulation of Connexin36 Gap Junction Channels by Intracellular Magnesium Ions

Frontiers in Physiology, 2022
Electrical synapses between neurons in the mammalian CNS are predominantly formed of the connexin36 (Cx36) gap junction (GJ) channel protein. Unique among GJs formed of a number of other members of the Cx gene family, Cx36 GJs possess a high sensitivity ...
Tadas Kraujalis, Tadas Kraujalis, Lukas Gudaitis, Lina Kraujaliene, Mindaugas Snipas, Mindaugas Snipas, Nicolás Palacios-Prado, Nicolás Palacios-Prado, Vytas K. Verselis   +8 more
doaj   +1 more source

Connexin Channels, Connexin Mimetic Peptides and ATP Release [PDF]

Cell Communication & Adhesion, 2003
Connexin hemichannels, that is, half gap junction channels (not connecting cells), have been implicated in the release of various messengers such as ATP and glutamate. We used connexin mimetic peptides, which are, small peptides mimicking a sequence on the connexin subunit, to investigate hemichannel functioning in endothelial cell lines.
Leybaert, L., Braet, K., Vandamme, W., Cabooter, L., Martin, P. E. M., Evans, W. H.   +5 more
openaire   +3 more sources

Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue

Reproductive Biology and Endocrinology, 2006
Background Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium.
Malmström Anders, Cebers Gvido, Dahlqvist Camilla, Klimaviciute Aurelija, Byström Birgitta, Cluff Ann, Ekman-Ordeberg Gunvor   +6 more
doaj   +1 more source

Upregulated and Hyperactivated Thalamic Connexin 43 Plays Important Roles in Pathomechanisms of Cognitive Impairment and Seizure of Autosomal Dominant Sleep-Related Hypermotor Epilepsy with S284L-Mutant α4 Subunit of Nicotinic ACh Receptor

Pharmaceuticals, 2020
To understand the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), we studied functional abnormalities of glutamatergic transmission in thalamocortical pathway from reticular thalamic nucleus (RTN ...
Kouji Fukuyama, Masashi Fukuzawa, Motohiro Okada   +2 more
doaj   +1 more source

Connexin Mutants and Cataracts [PDF]

Frontiers in Pharmacology, 2013
The lens is a multicellular, but avascular tissue that must stay transparent to allow normal transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins can cause cataracts, opacities that disrupt these processes.
Beyer, Eric C., Ebihara, Lisa, Berthoud, Viviana M.   +2 more
openaire   +3 more sources

Gap junction proteins and their role in spinal cord injury

Frontiers in Molecular Neuroscience, 2015
Gap junctions are specialized intercellular communication channels that are formed by two hexameric connexin hemichannels, one provided by each of the two adjacent cells.
Ryan S Tonkin, Yilin eMao, Simon J O`Carroll, Louise eNicholson, Colin eGreen, Catherine eGorrie, Gila eMoalem-Taylor   +6 more
doaj   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Beneficial and Detrimental Remodeling of Glial Connexin and Pannexin Functions in Rodent Models of Nervous System Diseases

Frontiers in Cellular Neuroscience, 2019
A variety of glial cell functions are supported by connexin and pannexin proteins. These functions include the modulation of synaptic gain, the control of excitability through regulation of the ion and neurotransmitter composition of the extracellular ...
Lucila Brocardo, Luis Ernesto Acosta, Ana Paula Piantanida, Lorena Rela   +3 more
doaj   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Cellular and deafness mechanisms underlying connexin mutation induced hearing loss – A common hereditary deafness

Frontiers in Cellular Neuroscience, 2015
Hearing loss due to mutations in the connexin gene family which encodes gap junctional proteins is a common form of hereditary deafness. In particular, connexin 26 (Cx26, GJB2) mutations are responsible for ~50% of nonsyndromic hearing loss, which is the
Jeffrey C Wingard, Hong-Bo eZhao
doaj   +1 more source