Results 111 to 120 of about 27,985 (262)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies.
Silvia Marchianò   +18 more
wiley   +1 more source

The Space Within: How Architected Voids Promote Tissue Formation

open access: yesAdvanced Materials, Volume 38, Issue 7, 2 February 2026.
This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou   +3 more
wiley   +1 more source

Hearing Loss: From Basic to Clinical Science

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
Abstract Hearing loss (HL) affects over 1.5 billion people globally, with genetic factors accounting for ≈50% of congenital cases. Therefore, HL has become a global health issue, driving extensive research from basic science to clinical applications. This Special Collection includes a total of 31 papers, among which 9 are review papers, 21 are research
Renjie Chai, Hai Huang, Jing Zou
wiley   +1 more source

GJB6 missense variant in a Labrador Retriever with paw pad hyperkeratosis

open access: yesAnimal Genetics, Volume 57, Issue 1, February 2026.
Abstract Palmoplantar keratoderma in humans is a condition defined by an abnormally thickened cornified skin layer on the hands and feet. In animals, the corresponding disease is commonly termed paw pad hyperkeratosis. It can be acquired due to repeated trauma, infections, cancer, or inflammatory dermatoses, or inherited due to pathogenic variants in ...
Stefan J. Rietmann   +3 more
wiley   +1 more source

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

open access: yesThe Anatomical Record, Volume 309, Issue 2, Page 417-450, February 2026.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna   +16 more
wiley   +1 more source

Trends in Chronic Ischemic Heart Disease‐Related Mortality in Older Adults With Atrial Fibrillation (1999–2023): A CDC WONDER Database Analysis

open access: yesClinical Cardiology, Volume 49, Issue 2, February 2026.
This study highlights rising age‐adjusted mortality rates from chronic ischemic heart disease in older adults with atrial fibrillation (1999–2023), with significant increases after 2010. Key disparities were observed by sex, race/ethnicity, urbanicity, and geography, emphasizing a need for targeted public health interventions ABSTRACT Introduction ...
Muhammad Shaheer Bin Faheem   +4 more
wiley   +1 more source

Erythrokeratoderma Variabilis Caused by p.Gly45Glu in Connexin 31: Importance of the First Extracellular Loop Glycine Residue for Gap Junction Function

open access: gold, 2015
Takuya Takeichi   +8 more
openalex   +2 more sources

Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability

open access: yesGlia, Volume 74, Issue 2, February 2026.
Astrocytic TCF7L2 impacts extracellular glutamate and glutamine levels. Loss of astrocytic TCF7L2 disrupts extracellular potassium clearance. TCF7L2‐dependent astrocytic changes reduce neuronal excitability. ABSTRACT Astrocytes differentiate and mature during postnatal development, but the molecular mechanisms linking their maturation to neuronal ...
Mariusz Popek   +10 more
wiley   +1 more source

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