Results 11 to 20 of about 42,664 (332)
Atrial Fibrillation: Focus on Myocardial Connexins and Gap Junctions
Biology, 2022 Atrial fibrillation (AF) represents the most common type of clinical cardiac arrhythmia worldwide and contributes to substantial morbidity, mortality and socioeconomic burden. Aggregating evidence highlights the strong genetic basis of AF. In addition to
Yu-Han Guo, Yi-Qing Yang
doaj +2 more sources
Journal of Biomedical Science, 2019 Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions among neighboring cells and thus facilitates gap junctional intercellular communication (GJIC).
Jun-I Wu, Lu-Hai Wang
doaj +2 more sources
Connexins in Cancer: Jekyll or Hyde?
Biomolecules, 2020 The expression, localization, and function of connexins, the protein subunits that comprise gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap junction channels, connexins also form hemichannels that allow ...
Erin E. Mulkearns-Hubert +2 more
doaj +2 more sources
Connexins and their channels in inflammation [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2016 Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury trigger, to clear out dead cells from damaged tissue and to initiate tissue regeneration.
Joost Willebrords +9 more
semanticscholar +5 more sources
Cardiology Research and Practice, 2012 Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further ...
Josephine A. Wright +2 more
doaj +3 more sources
Connexins and Integrins in Exosomes [PDF]
Cancers, 2019 Connexins and integrins, the two structurally and functionally distinct families of transmembrane proteins, have been shown to be inter-connected by various modes of cross-talk in cells, such as direct physical coupling via lateral contact, indirect ...
M. Shimaoka +4 more
semanticscholar +4 more sources
Extracellular cysteine in connexins: Role as redox sensors [PDF]
Frontiers in Physiology, 2016 Indexación: Scopus.Connexin-based channels comprise hemichannels and gap junction channels. The opening of hemichannels allow for the flux of ions and molecules from the extracellular space into the cell and vice versa.
Báez, D. +7 more
core +3 more sources
Connexins in the skeleton. [PDF]
Seminars in Cell & Developmental Biology, 2016 Shaping of the skeleton (modeling) and its maintenance throughout life (remodeling) require coordinated activity among bone forming (osteoblasts) and resorbing cells (osteoclasts) and osteocytes (bone embedded cells). The gap junction protein connexin43 (Cx43) has emerged as a key modulator of skeletal growth and homeostasis. The skeletal developmental
J. Stains, R. Civitelli
semanticscholar +4 more sources
Endothelial connexins in vascular function
Vascular Biology, 2019 Gap junctions are essential for intercellular crosstalk in blood and lymphatic vasculature. These clusters of intercellular channels ensure direct communication among endothelial cells and between endothelial and smooth muscle cells, and the ...
Aurélie Hautefort +2 more
doaj +2 more sources
Connexins : substrates and regulators of autophagy [PDF]
BMC Cell Biology, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
core +2 more sources