Results 211 to 220 of about 27,985 (262)
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Biochimie, 2010
The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Diane, Carette +3 more
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The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Diane, Carette +3 more
openaire +2 more sources
Connexins are mechanosensitive
American Journal of Physiology-Cell Physiology, 2004Connexins form gap junction channels that provide a hydrophilic path between cell interiors. Some connexins, particularly the lens connexins, Cx46 and Cx50 and their orthologs, can form functional hemichannels in nonjunctional membranes. These hemichannels are a nonselective conduit to the extracellular medium and may jeopardize cell survival.
Li, Bao, Frederick, Sachs, Gerhard, Dahl
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Biology of the Cell, 2002
Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Serre Beinier, Véronique +8 more
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Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Serre Beinier, Véronique +8 more
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Connexin-30 Deletion Analysis in Connexin-26 Heterozygotes
Genetic Testing, 2003Mutations in the Connexin-26 gene (Cx 26, GJB2) are the most common cause of hereditary nonsyndromic sensorineural hearing loss (SNHL). DNA analysis of the Cx 26 gene in deaf or hard-of-hearing individuals frequently demonstrates heterozygosity despite the fact that most mutations are known to be recessive. A 342-kb deletion in a gene adjacent to Cx 26,
Victoria A, Stevenson +2 more
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Biology of the Cell, 2002
Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
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Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
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2006
Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
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Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
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Connexins and β-cell functions
Diabetes Research and Clinical Practice, 2013Proper functioning of pancreatic islets requires that numerous β-cells are properly coordinated. With evolution, many mechanisms have converged, which now allow individual β-cells to sense the state of activity of their neighbors as well as the changes taking place in the extracellular medium, and to regulate accordingly their own function.
Cigliola Valentina +3 more
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Connexins and Cardiac Arrhythmias
2006During cardiac remodeling, impulse conduction in the heart is altered by changes in excitability, electrical coupling, and tissue architecture. The impairment of normal impulse conduction is one of the factors that increases the propensity for arrhythmias. This chapter focuses on the relationship between electrical coupling between ventricular myocytes
van Rijen, Harold V. M. +4 more
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Endothelial Connexin 37, Connexin 40, and Connexin 43 Respond Uniquely to Substrate and Shear Stress
Endothelium, 2007Endothelial connexins have been linked to atherosclerosis and hypertension; however, little is know about their sensitivity to stimuli and individual functions. This study investigates the responses of endothelial connexin 37, connexin 40, and connexin 43 (Cx37, Cx40, and Cx43) to shear stress and substrate.
Tiffany L, Johnson, Robert M, Nerem
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2010
Non-healing cutaneous wounds such as leg ulcers are a major cause of morbidity and mortality, especially in diabetes. Currently 67% of ulcers fail to respond to treatment after 20 weeks of care, and are a substantial time and cost burden. Recent studies suggest significant increases in skin wound healing rates occur by reduction of connexin (Cx ...
Wright, Catherine, Martin, Patricia
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Non-healing cutaneous wounds such as leg ulcers are a major cause of morbidity and mortality, especially in diabetes. Currently 67% of ulcers fail to respond to treatment after 20 weeks of care, and are a substantial time and cost burden. Recent studies suggest significant increases in skin wound healing rates occur by reduction of connexin (Cx ...
Wright, Catherine, Martin, Patricia
openaire +1 more source