Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. [PDF]
Marine Drugs, 2016 Cone snails are predatory creatures using venom as a weapon for prey capture and defense. Since this venom is neurotoxic, the venom gland is considered as an enormous collection of pharmacologically interesting compounds having a broad spectrum of ...
Eline K. M. Lebbe +9 more
doaj +3 more sources
Conotoxin Patenting Trends in Academia and Industry [PDF]
Marine Drugs, 2022 Sea snails of the genus Conus produce toxins that have been the subjects of numerous studies, projects, publications, and patents over the years. Since Conus toxins were discovered in the 1960s, their biological activity has been thought to have high ...
Noemi Sanchez-Campos +2 more
doaj +2 more sources
Diversity of Conopeptides and Their Precursor Genes of Conus Litteratus [PDF]
Marine Drugs, 2020 The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper, high-throughput transcriptome sequencing was performed to analyze putative conotoxin transcripts ...
Xinjia Li +3 more
openaire +4 more sources
Transcriptomic Analysis of Marine Gastropod Hemifusus tuba Provides Novel Insights into Conotoxin Genes [PDF]
Marine Drugs, 2019 The marine gastropod Hemifusus tuba is served as a luxury food in Asian countries and used in traditional Chinese medicine to treat lumbago and deafness. The lack of genomic data on H.
Ronghua Li +6 more
doaj +2 more sources
Snails In Silico: A Review of Computational Studies on the Conopeptides [PDF]
Marine Drugs, 2019 Marine cone snails are carnivorous gastropods that use peptide toxins called conopeptides both as a defense mechanism and as a means to immobilize and kill their prey. These peptide toxins exhibit a large chemical diversity that enables exquisite specificity and potency for target receptor proteins.
Rachael A. Mansbach +4 more
openaire +4 more sources
ConoServer: updated content, knowledge, and discovery tools in the conopeptide database
Nucleic Acids Research, 2011 ConoServer (http://www.conoserver.org) is a database specializing in the sequences and structures of conopeptides, which are toxins expressed by marine cone snails.
Q. Kaas +4 more
semanticscholar +4 more sources
A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide)
Angewandte Chemie, Volume 135, Issue 29, July 17, 2023., 2023 A chemoenzymatic method has been developed to prepare backbone cyclic analogues of the ω‐conotoxin MVIIA. The most potent cyclic analogue, cM‐7, shows highly improved stability and maintains the activity of the native peptide. Abstract Ziconotide (ω‐conotoxin MVIIA) is an approved analgesic for the treatment of chronic pain.
Yan Zhou +8 more
wiley +2 more sources
Correction: Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. [PDF]
J Biol Chem, 2020 M. Mohan +6 more
semanticscholar +2 more sources
Cupryphans, metal‐binding, redox‐active, redesigned conopeptides [PDF]
Protein Science, 2009 AbstractContryphans are bioactive peptides, isolated from the venom of marine snails of the genus Conus, which are characterized by the short length of the polypeptide chain and the high degree of unusual post‐translational modifications. The cyclization of the polypeptide chain through a single disulphide bond, the presence of two conserved Pro ...
BARBA, MARCO +7 more
openaire +6 more sources
Characterisation of a Novel A-Superfamily Conotoxin
Biomedicines, 2020 Conopeptides belonging to the A-superfamily from the venomous molluscs, Conus, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine ...
David T. Wilson +6 more
doaj +1 more source