Results 51 to 60 of about 1,008 (160)

Conotoxins: Therapeutic Potential and Application

Marine Drugs, 2006
The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides.
Richard T. Layer, J. Michael McIntosh
doaj   +1 more source

Structure-Function Elucidation of a New α-Conotoxin, MilIA, from Conus milneedwardsi

Marine Drugs, 2019
The a-Conotoxins are peptide toxins that are found in the venom of marine cone snails and they are potent antagonists of various subtypes of nicotinic acetylcholine receptors (nAChRs).
Steve Peigneur, Prabha Devi, Andrea Seldeslachts, Samuthirapandian Ravichandran, Loïc Quinton, Jan Tytgat   +5 more
doaj   +1 more source

Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells

Frontiers in Cellular Neuroscience, 2021
Efferent cholinergic neurons inhibit sensory hair cells of the vertebrate inner ear through the combined action of calcium-permeable α9α10-containing nicotinic acetylcholine receptors (nAChRs) and associated calcium-dependent potassium channels.
Fernando Fisher, Yuanyuan Zhang, Philippe F. Y. Vincent, Joanna Gajewiak, Thomas J. Gordon, Elisabeth Glowatzki, Paul Albert Fuchs, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh   +9 more
doaj   +1 more source

Allosteric α1-Adrenoreceptor Antagonism by the Conopeptide ρ-TIA [PDF]

Journal of Biological Chemistry, 2003
A peptide contained in the venom of the predatory marine snail Conus tulipa, rho-TIA, has previously been shown to possess alpha1-adrenoreceptor antagonist activity. Here, we further characterize its pharmacological activity as well as its structure-activity relationships.
Sharpe, Iain A., Thomas, Linda, Loughnan, Marion, Motin, Leonid, Palant, Elka, Croker, Daniel E., Alewood, Dianne, Chen, Songhai, Graham, Robert M., Alewood, Paul F., Adams, David J., Lewis, Richard J.   +11 more
openaire   +3 more sources

A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily. [PDF]

PLoS ONE, 2013
Conotoxins (CTxs) selectively target a range of ion channels and receptors, making them widely used tools for probing nervous system function. Conotoxins have been previously grouped into superfamilies according to signal sequence and into families based
Sulan Luo, Sean Christensen, Dongting Zhangsun, Yong Wu, Yuanyan Hu, Xiaopeng Zhu, Sandeep Chhabra, Raymond S Norton, J Michael McIntosh   +8 more
doaj   +1 more source

Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes

Toxins, 2018
Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide.
Andrea Figueroa-Montiel, Johanna Bernáldez, Samanta Jiménez, Beatrix Ueberhide, Luis Javier González, Alexei Licea-Navarro   +5 more
doaj   +1 more source

α‐RgIB: A Novel Antagonist Peptide of Neuronal Acetylcholine Receptor Isolated from Conus regius Venom

International Journal of Peptides, Volume 2013, Issue 1, 2013., 2013
Conus venoms are rich sources of biologically active peptides that act specifically on ionic channels and metabotropic receptors present at the neuromuscular junction, efficiently paralyzing the prey. Each species of Conus may have 50 to 200 uncharacterized bioactive peptides with pharmacological interest.
Maria Cristina Vianna Braga, Arthur Andrade Nery, Henning Ulrich, Katsuhiro Konno, Juliana Mozer Sciani, Daniel Carvalho Pimenta, Ayman El-Faham   +6 more
wiley   +1 more source

Overexpression, purification, and pharmacological activity of a biosynthetically derived conopeptide [PDF]

Biochemical and Biophysical Research Communications, 2005
A high yielding fusion protein system based on the protein cytochrome b(5) has been used for the production of novel 13-residue acyclic conopeptide. This peptide, Mo1659, can be liberated from the carrier protein using CNBr cleavage and subsequent purification using RP-HPLC methods. The yield of isotopically enriched peptides is high, ranging from 3 to
Kumar, Ganesan Senthil, Ramasamy, Palanisamy, Sikdar, Sujit K, Sarma, Siddhartha P   +3 more
openaire   +3 more sources

A Benchmark Dataset Comprising Partition and Distribution Coefficients of Linear Peptides

Dataset Papers in Science, Volume 2013, Issue 1, 2013., 2013
Peptides have a dominant role in biology; yet the study of their physical properties is at best sporadic. Peptide quantitative structure‐activity relationship (QSAR) lags far behind the QSAR analysis of drug‐like organic small molecules. Traditionally, QSAR has focussed on experimentally determined partition coefficients as the main descriptor of ...
Matthew N. Davies, Darren R. Flower, Liam McGuffin, Luis Alberto Ponce Soto   +3 more
wiley   +1 more source

Excitation–contraction coupling inhibitors potentiate the actions of botulinum neurotoxin type A at the neuromuscular junction

British Journal of Pharmacology, Volume 182, Issue 3, Page 564-580, February 2025.
Abstract Background and Purpose Botulinum neurotoxin type A1 (BoNT/A) is one of the most potent neurotoxins known. At the same time, it is also one of the safest therapeutic agents used for the treatment of several human disorders and in aesthetic medicine.
Mickaël Machicoane, Marika Tonellato, Marica Zainotto, Paul Onillon, Marco Stazi, Mattia Dal Corso, Aram Megighian, Ornella Rossetto, Jean‐Marc Le Doussal, Marco Pirazzini   +9 more
wiley   +1 more source