Results 71 to 80 of about 1,008 (160)

Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, Conus tulipa

Marine Drugs, 2019
The piscivorous cone snail Conus tulipa has evolved a net-hunting strategy, akin to the deadly Conus geographus, and is considered the second most dangerous cone snail to humans. Here, we present the first venomics study of C.
Mriga Dutt, Sébastien Dutertre, Ai-Hua Jin, Vincent Lavergne, Paul Francis Alewood, Richard James Lewis   +5 more
doaj   +1 more source

A vasopressin/oxytocin-related conopeptide with γ-carboxyglutamate at position 8 [PDF]

Biochemical Journal, 2007
Vasopressins and oxytocins are homologous, ubiquitous and multifunctional peptides present in animals. Conopressins are vasopressin/oxytocin-related peptides that have been found in the venom of cone snails, a genus of marine predatory molluscs that envenom their prey with a complex mixture of neuroactive peptides.
Carolina, Möller, Frank, Marí
openaire   +2 more sources

Conopeptide Vt3.1 Preferentially Inhibits BK Potassium Channels Containing β4 Subunits via Electrostatic Interactions*

Journal of Biological Chemistry, 2014
Background: BK channel function is differentially modulated by tissue-specific β (β1–4) subunits. Results: Conopeptide Vt3.1 preferentially inhibits neuronal BK channels containing the β4 subunit.
Min Li, Shan-Chun Chang, Longjin Yang, Jingyi Shi, Kelli McFarland, Xiao Yang, A. Moller, Chunguang Wang, X. Zou, C. Chi, J. Cui   +10 more
semanticscholar   +1 more source

Solution structures and thermodynamics of cis-trans X-Pro conformers of a novel single disulfide conopeptide

Indian Journal of Biochemistry & Biophysics, 2023

semanticscholar   +1 more source

Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain

Therapeutics and Clinical Risk Management, 2009
Howard S Smith,1 Timothy R Deer21Albany Medical College, Department of Anesthesiology, Albany, New York, USA; 2The Center for Pain Relief, Clinical Professor, West Virginia, University, Charleston, West Virginia, USAAbstract: Ziconotide is a conopeptide ...
Howard S Smith, Timothy R Deer
doaj  

Conopeptide ρ-TIA Defines a New Allosteric Site on the Extracellular Surface of the α1B-Adrenoceptor*♦

Journal of Biological Chemistry, 2012
Background: Mechanistic insight into allosteric modulation of GPCRs can facilitate antagonist design. Results: Extracellular surface residues (ECS) of the α1B-adrenoceptor at the base of extracellular loop 3 interact with the allosteric antagonist TIA ...
L. Ragnarsson, C. I. Wang, Åsa Andersson, Dewi Fajarningsih, Thea Monks, A. Brust, K. Rosengren, R. Lewis   +7 more
semanticscholar   +1 more source

Proteogenomic Assessment of Intraspecific Venom Variability: Molecular Adaptations in the Venom Arsenal of Conus purpurascens. [PDF]

Mol Cell Proteomics, 2021
Grandal M, Hoggard M, Neely B, Davis WC, Marí F.   +4 more
europepmc   +1 more source

Pharmacological profiles and anti-inflammatory activity of pCN-diEPP and mCN-diEPP, new alpha9alpha10 nicotinic receptor ligands. [PDF]

Neuropharmacology, 2023
Richter K, Herz SM, Stokes C, Damaj MI, Grau V, Papke RL.   +5 more
europepmc   +1 more source

Principal Component and Structural Element Analysis Provide Insights into the Evolutionary Divergence of Conotoxins. [PDF]

Biology (Basel), 2022
Kikuchi AKV, Tayo LL.
europepmc   +1 more source

Proteomic analysis of Red Sea Conus taeniatus venom reveals potential biological applications. [PDF]

J Venom Anim Toxins Incl Trop Dis, 2021
Fouda MMA, Abdel-Wahab M, Mohammadien A, Germoush MO, Sarhan M.   +4 more
europepmc   +1 more source