Results 141 to 150 of about 45,599 (229)

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes

Heliyon, 2019
In this study, we used reporter gene assays in COS-1 cells to examine the activation of rat pregnane X receptor (PXR), rat constitutive androstane receptor (CAR) and rat peroxisome-proliferator activated receptor (PPAR)α by pyrethroid pesticides, and to ...
Chieri Fujino, Yoko Watanabe, Seigo Sanoh, Hiroyuki Nakajima, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura   +8 more
doaj   +1 more source

Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens. [PDF]

, 2012
In recent years, accumulating evidence supports the importance of microRNAs in liver physiology and disease; however, few studies have examined the involvement of these noncoding genes in chemical hepatocarcinogenesis.
Currie, RA, Gooderham, NJ, Koufaris, C, Wright, J   +3 more
core   +1 more source

Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2

Toxicological Sciences, 2018
Exposure to environmentally relevant chemicals that activate the xenobiotic receptors aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), and peroxisome proliferator-activated receptor alpha (PPARα) in rodent test systems often leads
John P. Rooney, John P. Rooney, K. Oshida, K. Oshida, Ramiya Kumar, W. S. Baldwin, J. Corton   +6 more
semanticscholar   +1 more source

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

Toxicological Sciences, 2018
The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor involved in all phases of drug metabolism and disposition. However, recently it's been implicated in energy metabolism, tumor progression, and cancer therapy as well.
Caitlin Lynch, B. Mackowiak, Ruili Huang, Linhao Li, S. Heyward, S. Sakamuru, Hongbing Wang, M. Xia   +7 more
semanticscholar   +1 more source

The metabolic dysfunction-associated steatohepatitis (MASH) drug resmetirom exhibits broad nuclear receptor activity with minimal functional impact

Scientific Reports
In 2024, the FDA granted approval for resmetirom, a selective but moderately potent agonist of the thyroid hormone receptor (THR) β, marking the first drug for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) in the US.
Annette Kärcher, Laura Isigkeit, Nils Christiaan Bandomir, Manfred Schubert-Zsilavecz, Pascal Heitel   +4 more
doaj   +1 more source

Genetic susceptibility and pharmacogenetics of Multiple Myeloma [PDF]

, 2011
Multiple Myeloma (MM) is a hematological neoplasm that represent about 1% of all hematological malignancies. Several evidences have suggested the presence of genetic factor able to confer susceptibility to MM.
MARTINO, ALESSANDRO
core  

Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion [PDF]

, 2017
Gene regulatory interactions underlying the early stages of non-genotoxic carcinogenesis are poorly understood. Here, we have identified key candidate regulators of phenobarbital (PB)-mediated mouse liver tumorigenesis, a well-characterized model of non ...
Goodman, Jay I., Luisier, Raphaëlle, Moggs, Jonathan, Schwarz, Michael, Terranova, Rémi, Unterberger, Elif B., van Nimwegen, Erik   +6 more
core  

The constitutive androstane receptor mediates phenytoin induction of cyp2c37

The FASEB Journal, 2006
Cytochrome P450 monoxygenases (P450) are responsible for the metabolism and detoxification of many therapeutics. Induction of P450 enzymes by drugs can lead to potentially harmful drug‐drug interactions and alterations in drug therapy efficacy.
Jonathan Patrick Jackson, Stephen S. Ferguson, Masahiko Negishi, Joyce A Goldstein   +3 more
openaire   +1 more source

Constitutive Androstane Receptor Agonist, TCPOBOP: Maternal Exposure Impairs the Growth and Development of Female Offspring in Mice. [PDF]

Int J Mol Sci, 2023
Pan S, Guo Y, Yu W, Zhang J, Qiao X, Li L, Xu P, Zhai Y.   +7 more
europepmc   +1 more source

Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor. [PDF]

PLoS ONE, 2016
Marianne Mathäs, Christian Nusshag, Oliver Burk, Ute Gödtel-Armbrust, Holger Herlyn, Leszek Wojnowski, Björn Windshügel   +6 more
doaj   +1 more source