Results 141 to 150 of about 69,599 (292)

Spatial Transcriptomic Study Reveals Heterogeneous Metabolic Adaptation and a Role of Pericentral PPARα/CAR/Ces2a Axis During Fasting in Mouse Liver

Advanced Science, Volume 11, Issue 41, November 6, 2024.
Spatial transcriptomics reveals how mouse liver zonation adapts to nutritional changes, highlighting the pericentral nuclear receptor CAR as a key regulator of triglyceride metabolism. CAR activation, transcriptionally governed by PPARα, enhances lipolysis during fasting by upregulating carboxylesterase 2a, crucial for maintaining triglyceride ...
Shiguan Wang, Bowen Xu, Jinyuan Liang, Yawei Feng, Penghu Han, Jing Shen, Xinying Li, Mengqi Zheng, Tingguo Zhang, Cuijuan Zhang, Ping Mi, Yi Zhang, Zhiping Liu, Shiyang Li, Detian Yuan   +14 more
wiley   +1 more source

The Decrease in Farnesoid X Receptor, Pregnane X Receptor and Constitutive Androstane Receptor in the Liver after Intestinal Ischemia-Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2012
Purpose. Intestinal ischemia-reperfusion (I/R) damages remote organs, including the liver, and promotes multi-organ failure (MOF). However, the molecular mechanisms underlying acute liver injury after intestinal I/R have not been completely elucidated ...
Jiro Ogura, Yusuke Terada, Takashi Tsujimoto, Takahiro Koizumi, Kaori Kuwayama, Hajime Maruyama, Asuka Fujikawa, Atsushi Takaya, Masaki Kobayashi, Shirou Itagaki, Natsuko Takahashi, Takeshi Hirano, Hiroaki Yamaguchi, Ken Iseki   +13 more
doaj   +1 more source

Steroid–tacrolimus drug–drug interaction and the effect of CYP3A genotypes

British Journal of Clinical Pharmacology, Volume 90, Issue 11, Page 2837-2848, November 2024.
Abstract Aims Tacrolimus, metabolized by CYP3A4 and CYP3A5 enzymes, is susceptible to drug–drug interactions (DDI). Steroids induce CYP3A genes to increase tacrolimus clearance, but the effect is variable. We hypothesized that the extent of the steroid–tacrolimus DDI differs by CYP3A4/5 genotypes.
Abdelrahman Saqr, Mahmoud Al‐Kofahi, Moataz Mohamed, Casey Dorr, Rory P. Remmel, Guillaume Onyeaghala, William S. Oetting, Weihua Guan, Roslyn B. Mannon, Arthur J. Matas, Ajay Israni, Pamala A. Jacobson   +11 more
wiley   +1 more source

Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)

Acta Pharmaceutica Sinica B, 2021
Crosstalk between xenobiotic metabolism and energy metabolism in the liver has provided a potential opportunity to target xenobiotic receptors to treat metabolic diseases. Activation of constitutive androstane receptor (CAR), a xenobiotic-sensing nuclear
Xinran Cai, Ye Feng, Meishu Xu, Chaohui Yu, Wen Xie   +4 more
doaj  

Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor [PDF]

, 2004
BACKGROUND: The constitutive androstane receptor (CAR) plays a key role in the control of drug metabolism and transport by mediating the phenobarbital-type induction of many phase I and II drug metabolizing enzymes and drug transporters.
Arnold, Katja A, Burk, Oliver, Eichelbaum, Michel   +2 more
core   +2 more sources

Effects of hypothermia and hypoxia on cytochrome P450‐mediated drug metabolism in neonatal Göttingen minipigs

Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 5, Page 620-640, November 2024.
Abstract Asphyxiated neonates often undergo therapeutic hypothermia (TH) to reduce morbidity and mortality. As perinatal asphyxia and TH impact neonatal physiology, this could also influence enzyme functionality. Therefore, this study aimed to unravel the impact of age, hypothermia and hypoxia on porcine hepatic cytochrome P450 (CYP) gene expression ...
Marina‐Stefania Stroe, Laura De Clerck, Maarten Dhaenens, Rachel Siân Dennis, Dieter Deforce, Sebastien Carpentier, Pieter Annaert, Karen Leys, Anne Smits, Karel Allegaert, Chris Van Ginneken, Steven Van Cruchten   +11 more
wiley   +1 more source

The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation

The FASEB Journal, Volume 38, Issue 20, 31 October 2024.
Cyp2c55 is highly expressed in the colonic epithelial cells of mice in a microbiota‐dependent manner. The underlying mechanism seems to involve a BA‐mediated PXR activation. Furthermore, the colonic expression of Cyp2c55 is also subject to regulation by the inflammatory response. While the physiological function of Cyp2c55 remains largely unidentified,
Adrian Hilman, Tetsu Sato, Bambang Dwi Wijatniko, So Fujimura, Katsushi Nakamura, Hiroto Miura, Ken Iwatsuki, Ryo Inoue, Takuya Suzuki   +8 more
wiley   +1 more source

Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

Toxicological Sciences, 2018
The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor involved in all phases of drug metabolism and disposition. However, recently it's been implicated in energy metabolism, tumor progression, and cancer therapy as well.
Caitlin Lynch, B. Mackowiak, Ruili Huang, Linhao Li, S. Heyward, S. Sakamuru, Hongbing Wang, M. Xia   +7 more
semanticscholar   +1 more source

Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion [PDF]

, 2017
Gene regulatory interactions underlying the early stages of non-genotoxic carcinogenesis are poorly understood. Here, we have identified key candidate regulators of phenobarbital (PB)-mediated mouse liver tumorigenesis, a well-characterized model of non ...
Goodman, Jay I., Luisier, Raphaëlle, Moggs, Jonathan, Schwarz, Michael, Terranova, Rémi, Unterberger, Elif B., van Nimwegen, Erik   +6 more
core  

Identification of a Safe and Tolerable Carbamazepine Dosing Paradigm that Facilitates Effective Evaluation of CYP3A4 Induction

Clinical Pharmacology &Therapeutics, Volume 116, Issue 4, Page 1034-1041, October 2024.
Carbamazepine (CBZ) is the recommended alternative to rifampicin as a CYP3A4 inducer in drug–drug interaction studies. However, the traditional CBZ dosing paradigm can lead to several adverse events (AEs). This study tested a shorter CBZ dosing regimen using the CYP3A4‐sensitive index substrate midazolam (MDZ).
Amita Datta‐Mannan, Elaine Shanks, Eunice Yuen, Yan Jin, Jessica Rehmel, Stephen David Hall   +5 more
wiley   +1 more source