Results 151 to 160 of about 69,599 (292)
Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy [PDF]
, 2011 Natural organosulfur compounds (OSCs) have been shown to have chemopreventive effects and to suppress the proliferation of tumor cells in vitro through the induction of apoptosis.
Melino, S, Paci, M, Sabelli, R
core +1 more source
SVM Model for Identification of human GPCRs [PDF]
Journal of Computing, Volume 2, Issue 2, February 2010,
https://sites.google.com/site/journalofcomputing/, 2010 G-protein coupled receptors (GPCRs) constitute a broad class of cell-surface receptors in eukaryotes and they possess seven transmembrane a-helical domains. GPCRs are usually classified into several functionally distinct families that play a key role in cellular signalling and regulation of basic physiological processes.
arxiv
A Thermodynamic Model for Receptor Clustering [PDF]
, 1999 Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affects the signal transduction.
arxiv +1 more source
Investigating the molecular basis for the constitutive activity of the nuclear hormone receptor CAR [PDF]
, 2006 Der constitutive androstane receptor (CAR) gehört zur Superfamilie der Kernhormon-Rezeptoren. Die einzelnen Mitglieder dieser Familie stellen liganden-aktivierte Transkriptionsfaktoren dar, die zahlreiche zelluläre Prozesse regulieren, darunter sowohl ...
Windshügel, Björn Anselm
core +1 more source
Scientific Reports, 2019 Bisphenol A (BPA) is used as an industrial raw material for polycarbonate plastics and epoxy resins; however, various concerns have been reported regarding its status as an endocrine-disrupting chemical.
Takahiro Masuya +3 more
doaj +1 more source
Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens. [PDF]
, 2012 In recent years, accumulating evidence supports the importance of microRNAs in liver physiology and disease; however, few studies have examined the involvement of these noncoding genes in chemical hepatocarcinogenesis.
Currie, RA +3 more
core +1 more source
Structure and dynamics of dynorphin peptide and its receptor [PDF]
arXiv, 2019 Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv
Hepatology Communications, 2018 Bile acid (BA) homeostasis is tightly regulated by multiple transcription factors, including farnesoid X receptor (FXR) and small heterodimer partner (SHP).
K. Kim +9 more
semanticscholar +1 more source
The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals [PDF]
, 2004 BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals.
Blättler, Sharon +8 more
core +3 more sources
Detection in Molecular Communications with Ligand Receptors under Molecular Interference [PDF]
arXiv, 2020 Molecular Communications (MC) is a bio-inspired communication technique that uses molecules to transfer information among bio-nano devices. In this paper, we focus on the detection problem for biological MC receivers employing ligand receptors to infer the transmitted messages encoded into the concentration of molecules, i.e., ligands.
arxiv