Journal of Pharmacology and Experimental Therapeutics, 2019 Adenosine deaminases acting on RNA (ADARs) enzymes-catalyzing adenosine-to-inosine RNA editing possibly modulates gene expression and function. In this study, we investigated whether ADARs regulate the expression of human constitutive androstane receptor
Masataka Nakano, T. Fukami, M. Nakajima
semanticscholar +1 more source
Rational quantitative structure–activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands [PDF]
, 2010 Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are closely related orphan nuclear receptor proteins that share several ligands and target overlapping sets of genes involved in homeostasis and all phases of drug metabolism.
Anderson, Linnea E. +3 more
core +2 more sources
Flexible protein-peptide docking using CABS-dock with knowledge about the binding site [PDF]
arXiv, 2016 Despite considerable efforts, structural prediction of protein-peptide complexes is still a very challenging task, mainly due to two reasons: high flexibility of the peptides and transient character of their interactions with proteins. Recently we have developed an automated web server CABS-dock (http://biocomp.chem.uw.edu.pl/CABSdock), which conducts ...
arxiv
Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids [PDF]
, 2016 The liver is essential for survival due to its critical role in the regulation of metabolic homeostasis. Metabolism of xenobiotics, such as environmental chemicals and drugs by the liver protects us from toxic effects of these xenobiotics, whereas ...
Lu, Hong
core +2 more sources
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands [PDF]
, 2000 Linda B. Moore +11 more
openalex +1 more source
Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers [PDF]
, 2009 Background Detoxification in the liver involves activation of nuclear receptors, such as the constitutive androstane receptor (CAR), which regulate downstream genes of xenobiotic metabolism.
Björkhem, Ingemar +5 more
core +3 more sources
Conservation of Signaling Pathways of Xenobiotic-Sensing Orphan Nuclear Receptors, Chicken Xenobiotic Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor, from Birds to Humans [PDF]
, 2001 Christoph Handschin
openalex +1 more source
Frontiers in Pharmacology, 2018 The constitutive androstane receptor (CAR) is a nuclear receptor involved mainly in xenobiotic and endobiotic metabolism regulation. CAR is activated directly by its ligands via the ligand binding domain (LBD) or indirectly by inhibition of the epidermal
A. Carazo +8 more
semanticscholar +1 more source
THE ROLE OF CAR AND PXR IN TOXICANT SENSITIVITY [PDF]
, 2010 The Constitutive Androstane Receptor (CAR) and the Pregnane X Receptor (PXR) are nuclear receptors of significant importance in the regulation of enzymes that metabolize, detoxify and eliminate compounds from the body.
Mota, Linda
core +1 more source
Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors [PDF]
, 2002 Linda B. Moore +7 more
openalex +1 more source