Results 101 to 110 of about 2,179,886 (275)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Five-dimensional N = 4 Supersymmetric Mechanics
Acta Polytechnica, 2011 We perform an su(2) Hamiltonian reduction in the bosonic sector of the su(2)-invariant action for two free (4, 4, 0) supermultiplets. As a result, we get the five dimensional N = 4 supersymmetric mechanics describing the motion of an isospin carrying ...
S. Bellucci, S. Krivonos, A. Sutulin
doaj
Russian Journal of Education and PsychologyThis article considers the actual issue about reflection development because despite various reflection development practice existence there are no precise tools for reflective action formation.
Sofya I. Dreytser
doaj +1 more source
New classes of modified teleparallel gravity models
Physics Letters B, 2017 New classes of modified teleparallel theories of gravity are introduced. The action of this theory is constructed to be a function of the irreducible parts of torsion f(Tax,Tten,Tvec), where Tax,Tten and Tvec are squares of the axial, tensor and vector ...
Sebastian Bahamonde +2 more
doaj +1 more source
Easy insert, easy release toggle bolt fastener [PDF]
, 1970 Releasable pin-type toggle bolt fastener is constructed so that, when positioned in hole, toggle action prevents its removal and locknut anchors it firmly in place.
Kubokawa, C. C.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Quantum Super-Integrable Systems as Exactly Solvable Models
Symmetry, Integrability and Geometry: Methods and Applications, 2007 We consider some examples of quantum super-integrable systems and the associated nonlinear extensions of Lie algebras. The intimate relationship between super-integrability and exact solvability is illustrated.
Allan P. Fordy
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source