Results 51 to 60 of about 656,425 (290)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Role of the Emotional Sequence in the Communication of the Territorial Cheeses: A Neuromarketing Approach

Foods, 2022
Over the past few years, many studies have shown how territoriality can be considered a driver for purchasing agri-food products. Products with certification of origin are perceived as more sustainable, safer and of better quality.
Vincenzo Russo, Marco Bilucaglia, Riccardo Circi, Mara Bellati, Riccardo Valesi, Rita Laureanti, Giuseppe Licitra, Margherita Zito   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Antecedents and outcomes of consumer environmentally friendly attitudes and behaviour [PDF]

, 2010
With the intensification of problems relating to the environment, a growing number of consumers are becoming more ecologically conscious in their preferences and purchases of goods.
Aitken L., Bentler P.M., Byrne B.M., Constantinos N. Leonidou, Dunlap R.E., Eigner S., Ellen P.S., Festinger L., Flatters P., García-Rosell J.-C., Hair J.F., Hofstede G., Hofstede G., Jones A., Kim Y., Kline R.B., Leonidas C. Leonidou, Levin G., Light H., Mayer F.S., McCarty J., Melillo W., Newell S.J., Nigbur D., Nisbet E.K., Nunnally J.C., O'Neill J., Olga Kvasova, Olli E., Paim L., Paladino A., Pickett G.M., Porritt J., Schuhwerk M.E., Shabecoff P., Sinha J.B.P., Sohr S., Solomon M., Triandis H.C.   +38 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Integrating Food Biodiversity into Public Food Procurement: A Brazilian Amazon Case of Indigenous Peoples and Local Communities

Journal of Sustainability
This study explores the integration of food biodiversity and Indigenous Peoples (IPs) and Local Communities (LCs) into public food procurement (PFP). Using a primarily qualitative approach, it combines a scoping review with a case study of the National ...
Biancada da Conceição Cabral, Teresa Borelli, Andrea das Graças Ferreira Frazao, Bernardo Tomchinsky, Sharon Mendonce, Danny Hunter   +5 more
doaj   +1 more source

User-documented food consumption data from publicly available apps: an analysis of opportunities and challenges for nutrition research

Nutrition Journal, 2018
Background The need for a better understanding of food consumption behaviour within its behavioural context has sparked the interest of nutrition researchers for user-documented food consumption data collected outside the research context using publicly ...
Marcus Maringer, Pieter van’t Veer, Naomi Klepacz, Muriel C. D. Verain, Anne Normann, Suzanne Ekman, Lada Timotijevic, Monique M. Raats, Anouk Geelen   +8 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source