Results 51 to 60 of about 1,627,092 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Trim Strategy, Control Model, and Flight Dynamics Characteristics of Canard Rotor/Wing Aircraft in Transition Mode

IEEE Access, 2019
The transition mode of canard rotor/wing (CRW) aircraft is complex and important. During the transition flight, components that generate lift are transferred from one to another, in addition, the redundancy of control system may induce control conflict ...
Honggang Gao, Zhenghong Gao, Yang Na, Chao Pang   +3 more
doaj   +1 more source

Optimal Vaccine Allocation to Control Epidemic Outbreaks in Arbitrary Networks

, 2013
We consider the problem of controlling the propagation of an epidemic outbreak in an arbitrary contact network by distributing vaccination resources throughout the network.
Enyioha, Chinwendu, Jadbabaie, Ali, Pappas, George, Preciado, Victor M., Zargham, Michael   +4 more
core   +1 more source

Reducing avoidable inequalities in health: a new criterion for setting health care capitation payments [PDF]

, 2002
Traditionally, most health care systems which pretend to any sort of rationality and cost control have sought to allocate their limited funds in order to secure equal opportunity of access for equal need.
Acheson, Andersson, Carr-Hill, Croxson, Culyer, Culyer, Culyer, Department of Health, Department of Health, Department of Health and Social Security, Department of Health and Social Services, Goddard, Gordon, Häkkinen, Lindholm, Mooney, NHS Centre for Reviews and Dissemination, Pampalon, Pereira, Resource Allocation Working Party, Rice, Royston, Scottish Executive Health Department, Shmueli, Smith, Sutton, Wagstaff, Welsh Office, Whynes, Williams, Williams   +30 more
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Control Allocation for an Over-Actuated Aircraft Based on Within-Visual-Range Air Combat Agility

IEEE Access, 2018
The control allocation problems of an over-actuated aircraft are studied to fully utilize the within-visual-range (WVR) air combat agility. By analyzing the agility requirements of modern WVR air combat, a control effector superiority evaluating method ...
Yan Liu, Zhenghong Gao, Chongyang Shang
doaj   +1 more source

Control Allocation with Load Balancing [PDF]

AIAA Guidance, Navigation, and Control Conference, 2009
Next generation aircraft with a large number of actuators will require advanced control allocation methods to compute the actuator commands needed to follow desired trajectories while respecting system constraints. Previously, algorithms were proposed to minimize the l1 or l2 norms of the tracking error and of the actuator deflections.
Marc Bodson, Susan Frost
openaire   +1 more source

A Hierarchical Framework of Cloud Resource Allocation and Power Management Using Deep Reinforcement Learning

, 2017
Automatic decision-making approaches, such as reinforcement learning (RL), have been applied to (partially) solve the resource allocation problem adaptively in the cloud computing system.
Li, Zhe, Lin, Sheng, Liu, Ning, Qiu, Qinru, Tang, Jian, Wang, Yanzhi, Xu, Jielong, Xu, Zhiyuan   +7 more
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Auction-Based Distributed Resource Allocation for Cooperation Transmission in Wireless Networks

, 2007
Cooperative transmission can greatly improve communication system performance by taking advantage of the broadcast nature of wireless channels. Most previous work on resource allocation for cooperation transmission is based on centralized control.
Chiang, Mung, Han, Zhu, Huang, Jianwei, Poor, H. Vincent   +3 more
core   +2 more sources