Results 131 to 140 of about 6,209 (262)

Microdosimetry calculations in situ for clinically relevant photon sources and their correlation with the early DNA damage response. [PDF]

Med Phys
Dumančić M, Kalinowski J, Diaz-Martinez VD, Li J, Behmand B, DeCunha JM, Enger SA.   +6 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evaluation of relative biological effectiveness of ²²⁵Ac and its decay daughters with Monte Carlo track structure simulations. [PDF]

EJNMMI Phys
Hu Z, Qu S, Liu H, Zhang Y, Yan S, Hu A, Qiu R, Wu Z, Zhang H, Li J.   +9 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Serum metabolic and microbial profiling yields insights into promoting effect of tryptophan-related metabolites for health longevity in centenarians. [PDF]

Imeta
Qiu X, Mu C, Hu J, Yu J, Tang W, Liu Y, Huang Y, Lu Y, Tang P, Wu J, Huang Z, Mei X, Xiang H, Lin H, Qi Y, Luo H, Li X.   +16 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

[Flagellate erythema secondary to bleomycin: case report with favorable outcome]. [PDF]

Rev Med Inst Mex Seguro Soc
Leal-León R, Tirado-Motel A, Escribano-Ponce M, González-Ruiz V, Vega-González MTJ.   +4 more
europepmc   +1 more source

Control robust per a sistemes no lineals

Aquest treball de final d’estudis descriu com dissenyar un prototip de levitador magnètic de baix cost econòmic. La levitació magnètica, també anomenada MagLev, és la interacció entre camps magnètics que generen forces d’atracció o de repulsió per eliminar la força del pes d’un objecte. El levitador consisteix en un actuador, en aquest cas un solenoide,
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Prospective assessment on the cephalometric profile changes induced by labial hyaluronic acid infiltrations: A before-and-after study. [PDF]

J Clin Exp Dent
Carrero-Brioso P, Baus-Domínguez M, Ruiz-de-Leon G, Keim-Del-Pino C, Serrera-Figallo MA, Vazquez-Pachon C, Torres-Lagares D, Gutierrez-Perez JL.   +7 more
europepmc   +1 more source