Results 141 to 150 of about 13,466 (296)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Desenvolvimento de um simulador e controle preditivo de uma coluna de destilição piloto [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.O presente trabalho aborda o desenvolvimento de um simulador protótipo e a aplicação de controle preditivo baseado em ...
Bravo, Claudio Osvaldo Ayala
core  

Desarrollo del vehículo eléctrico tipo transportador personal

Perspectivas, 2019
El artículo presenta la construcción de un vehículo eléctrico tipo Segway de dos ruedas, a partir del diseño de cada una de sus partes y la aplicación de la ingeniería inversa, para su desarrollo en Ecuador.
Víctor Velasco-Ulco, Alexandra Chuquitarco-Aguayo, Edilberto Antonio Llanes-Cedeño, Juan Carlos Rocha-Hoyos   +3 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Herramientas interactivas para el control de sistemas no lineales

, 2021
The objective of this file is to document the work done in the design and development of an interactive tool for the study and teaching of nonlinear systems' control theory and, in particular, of the Describing Function Method. This tool, developed using the software Sysquake, was requested by the department of Systems Engineering, Automatics and ...
openaire   +2 more sources

Control Lineal y No Lineal de un Levitador Magnético. Estudio Comparativo

En el ámbito de la investigación existen gran variedad de trabajos relacionados con el control de levitadores magnéticos, algunos de estos trabajos comprueban sus resultados únicamente mediante simulación y otros utilizan resultados experimentales o ...
Milena Moreno, Juan Carlos
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Control de velocidad del motor de indución empleando linealización por realimentación de estados

Revista Ingenierías Universidad de Medellín, 2011
Este documento presenta la aplicación de la técnica de control no lineal clásica llamada linealización por realimentación de variables de estado. Se hace una aplicación en el motor de inducción, la variable a controlar es la velocidad del eje
Eduardo Giraldo Suárez, Santiago Sánchez Acevedo   +1 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Control robust per a sistemes no lineals

Aquest treball de final d’estudis descriu com dissenyar un prototip de levitador magnètic de baix cost econòmic. La levitació magnètica, també anomenada MagLev, és la interacció entre camps magnètics que generen forces d’atracció o de repulsió per eliminar la força del pes d’un objecte. El levitador consisteix en un actuador, en aquest cas un solenoide,
openaire   +1 more source