Results 91 to 100 of about 2,314,627 (288)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Polymer carriers for controlled fragrance release

Materials Research Express, 2020
Fragrance is a class of material commonly used in many consumer products such as food and tobacco. Since most of the fragrance is highly volatile, the successful use of fragrance in practical application requires effective preservation of fragrance with ...
Min Wei, Xi Pan, Lin Rong, Aijun Dong, Yunlu He, Xuyan Song, Junsheng Li   +6 more
doaj   +1 more source

Free boundary problems in controlled release pharmaceuticals. I: diffusion in glassy polymers [PDF]

, 1988
This paper formulates and studies two different problems occurring in the formation and use of pharmaceuticals via controlled release methods. These problems involve a glassy polymer and a penetrant, and the central problem is to predict and control the ...
Cohen, Donald S., Erneux, Thomas
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Simulating California reservoir operation using the classification and regression-tree algorithm combined with a shuffled cross-validation scheme [PDF]

, 2016
The controlled outflows from a reservoir or dam are highly dependent on the decisions made by the reservoir operators, instead of a natural hydrological process.
Gao, X, Li, X, Sorooshian, S, Yang, T
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Development of a Thiolated Carboxymethyl tara gum derivative with enhanced mucoadhesive and rheological behavior

Carbohydrate Polymer Technologies and Applications
The rational design of thiolated polysaccharides offers new opportunities to enhance the performance of gastroretentive drug delivery systems by improving mucoadhesive and rheological properties.
Manuel Pariguana, Liz Gonzalez, Clément de Loubens, Esteban Vargas, Adolfo Marican, Ricardo Castro, Gustavo Cabrera-Barjas, Esteban F. Durán-Lara   +7 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source