Results 301 to 310 of about 6,856,628 (321)

Isolation of Conventional Murine Lung Dendritic Cell Subsets

Current Protocols in Immunology, 2018
AbstractThe lungs are continuously exposed to environmental threats, requiring an adequate and stringent immune response of a heterogeneous set of effector cells. Dendritic cells (DCs) form a dense network in the respiratory mucosa and act as the central regulators of the different components of this response, both sensing the nature of the threats and
Cédric, Bosteels, Bart N, Lambrecht, Hamida, Hammad   +2 more
openaire   +2 more sources

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

Nature Immunology, 2009
Little is known of how and where bacterial recognition triggers the induction of type I interferon. Whether the type of recognition receptor used in these responses is determined by the subcellular location of bacteria is not understood. Here we show that phagosomal bacteria such as group B streptococcus, but not cytosolic bacteria, potently induced ...
MANCUSO, Giuseppe, Gambuzza M, MIDIRI, Angelina, BIONDO, Carmelo, PAPASERGI, salvatore, Akira S, TETI, Giuseppe, BENINATI, Concetta   +7 more
openaire   +3 more sources

Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

Science immunology, 2020
Immunity to inhaled antigens is governed by inflammatory signals that alter the composition of DC subsets within the NALTs. A nose for inflammation The nasal-associated lymphoid tissues (NALTs) are lymphoid organs in the nasal mucosa that are sites of ...
James G. Bedford, Melanie Heinlein, A. Garnham, Thi H. O. Nguyen, T. Loudovaris, Chenghao Ge, Stuart I. Mannering, Michael Elliott, S. Tangye, K. Kedzierska, D. Gray, W. Heath, L. Wakim   +12 more
semanticscholar   +1 more source

Isolation of Conventional Dendritic Cells from Mouse Lungs

2016
The lungs are in direct contact with the environment. Separated only by a thin layer of mucosa, the lung immune system is being exposed to dangers like pathogens, allergens, or pollutants. The lung dendritic cells form an elaborate network at the basolateral side of the epithelium and continuously sample antigens from the airway lumen. The conventional
Lianne, van de Laar, Martin, Guilliams, Simon, Tavernier   +2 more
openaire   +2 more sources

The Generation of Plasmacytoid and Conventional Dendritic Cells with M-CSF

2009
Mice lacking the ligand for Flt-3 (CD135) have a massive deficit of dendritic cells (DC) in all organs. This phenotype of FL (FL) knockout mice suggested that FL was the archetypal DC poietin in the steady state. However, FL knockout mice also have reduced numbers of common lymphoid progenitors (CLP) and common myeloid progenitors (CMP) so it is ...
Meredith, O'Keeffe, Ben, Fancke, Hubertus, Hochrein   +2 more
openaire   +2 more sources

Phenotype and functions of conventional dendritic cells are not compromised in aged mice

Immunology & Cell Biology, 2012
Aging has profound effects on the immune system, including thymic involution, reduced diversity of the T cell receptor repertoire, reduced effector T cell and B cell function and chronic increase of proinflammatory cytokine production by innate immune cells. The precise effects of aging on conventional dendritic cells (cDC), the main antigen presenting
Sioh-Yang, Tan, Lois L, Cavanagh, William, d'Advigor, Nick, Shackel, Barbara, Fazekas de St Groth, Wolfgang, Weninger   +5 more
openaire   +2 more sources

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Nature Medicine, 2021
Aleksandra Deczkowska, Eyal David, P. Ramadori, D. Pfister, M. Safran, Baoguo Li, A. Giladi, Diego Jaitin, Oren Barboy, Merav Cohen, Ido Yofe, C. Gur, Shir Shlomi-Loubaton, S. Henri, Yousuf Suhail, Meng-Jie Qiu, S. Kam, H. Hermon, E. Lahat, G. Ben Yakov, O. Cohen-ezra, Y. Davidov, M. Likhter, D. Goitein, S. Roth, A. Weber, B. Malissen, A. Weiner, Z. Ben‐Ari, Mathias F. Heikenwälder, E. Elinav, I. Amit   +31 more
semanticscholar   +1 more source

Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells

Immunity, 2022
Nicholas Adams, Jue Feng, Marcela Alcántara-Hernández   +2 more
exaly  

CAR-T cells and CAR-Tregs targeting conventional type-1 dendritic cell suppress experimental autoimmune encephalomyelitis

Frontiers in Immunology, 2023
Hyewon Phee
exaly  

Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity

Cellular and Molecular Immunology, 2022
Emma Cook, Salvador Iborra, Francisco J Cueto   +2 more
exaly