Results 1 to 10 of about 16,152 (159)
Loss of Arabidopsis β-COP Function Affects Golgi Structure, Plant Growth and Tolerance to Salt Stress [PDF]
Frontiers in Plant Science, 2020 The early secretory pathway involves bidirectional transport between the endoplasmic reticulum (ER) and the Golgi apparatus and is mediated by coat protein complex I (COPI)-coated and coat protein complex II (COPII)-coated vesicles.
Judit Sánchez-Simarro +6 more
doaj +5 more sources
Current Biology, 2016 Approximately one third of a cell's proteins are destined to function outside the cell's boundaries or while embedded within cellular membranes. Ensuring these proteins reach their diverse final destinations with temporal and spatial accuracy is essential for cellular physiology.
Gomez-Navarro, Natalia +1 more
openaire +3 more sources
En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles. [PDF]
The Journal of cell biology, 1994 The cDNA encoding epsilon-COP, the 36-kD subunit of coatomer, was cloned from a bovine liver cDNA library and sequenced. Immunoblotting with an anti-epsilon-COP antibody showed that epsilon-COP exists in COP-coated vesicles as well as in the cytosolic coatomer.
S, Hara-Kuge +6 more
openaire +3 more sources
Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles. [PDF]
The Journal of cell biology, 1993 The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation factor (ARF), helps to provide vectoriality to vesicle transport. Coat assembly is triggered when ARF binds GTP, initiating transport vesicle budding, and coat disassembly is triggered when ARF hydrolyzes GTP, allowing the uncoated vesicle to fuse.
Tanigawa, G +5 more
openaire +4 more sources
zeta-COP, a subunit of coatomer, is required for COP-coated vesicle assembly. [PDF]
The Journal of cell biology, 1993 cDNA encoding the 20-kD subunit of coatomer, zeta-COP, predicts a protein of 177-amino acid residues, similar in sequence to AP17 and AP19, subunits of the clathrin adaptor complexes. Polyclonal antibody directed to zeta-COP blocks the binding of coatomer to Golgi membranes and prevents the assembly of COP-coated vesicles on Golgi cisternae.
O, Kuge +7 more
openaire +3 more sources
COP-coated vesicles are involved in the mitotic fragmentation of Golgi stacks in a cell-free system. [PDF]
The Journal of cell biology, 1994 Rat liver Golgi stacks fragmented when incubated with mitotic but not interphase cytosol in a process dependent on time, temperature, energy (added in the form of ATP) and cdc2 kinase. The cross-sectional length of Golgi stacks fell in the presence of mitotic cytosol by approximately 50% over 30 min without a corresponding decrease in the number of ...
T, Misteli, G, Warren
openaire +3 more sources
Rsp5 ubiquitin ligase is required for protein trafficking in Saccharomyces cerevisiae COPI mutants. [PDF]
PLoS ONE, 2012 Retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) depends on the formation of vesicles coated with the multiprotein complex COPI.
Katarzyna Jarmoszewicz +3 more
doaj +7 more sources
Cex1 is a component of the COPI intracellular trafficking machinery
Biology Open, 2021 COPI (coatomer complex I) coated vesicles are involved in Golgi-to-ER and intra-Golgi trafficking pathways, and mediate retrieval of ER resident proteins. Functions and components of the COPI-mediated trafficking pathways, beyond the canonical set of Sec/
Ludovic Enkler +7 more
doaj +1 more source
The spinal muscular atrophy disease protein SMN is linked to the Golgi network. [PDF]
PLoS ONE, 2012 Proximal spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by deficiency of the ubiquitous Survival of Motor Neuron (SMN) protein. SMN has been shown to be transported in granules along the axon and moved through cytoskeletal elements.
Chen-Hung Ting +5 more
doaj +1 more source
The complexity of vesicle transport factors in plants examined by orthology search. [PDF]
PLoS ONE, 2014 Vesicle transport is a central process to ensure protein and lipid distribution in eukaryotic cells. The current knowledge on the molecular components and mechanisms of this process is majorly based on studies in Saccharomyces cerevisiae and Arabidopsis ...
Puneet Paul +5 more
doaj +1 more source