Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication [PDF]
, 2012 All positive strand RNA viruses are known to replicate their genomes in close association with intracellular membranes. In case of the hepatitis C virus (HCV), a member of the family Flaviviridae, infected cells contain accumulations of vesicles forming ...
Antony, Claude +13 more
core +3 more sources
Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E. +4 more
core +2 more sources
A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi. [PDF]
, 2017 Capitalizing on CRISPR/Cas9 gene-editing techniques and super-resolution nanoscopy, we explore the role of the small GTPase ARF1 in mediating transport steps at the Golgi.
Baddeley, David +12 more
core +2 more sources
Involvement of the transmembrane protein p23 in biosynthetic protein transport [PDF]
, 1997 The identification of ANO1/TMEM16A as the likely calcium-dependent chloride channel of exocrine glands has led to a more detailed understanding of its biophysical properties.
Alcalde +74 more
core +2 more sources
Differential Requirements for COPI Coats in Formation of Replication Complexes among Three Genera of Picornaviridae [PDF]
, 2002 Picornavirus RNA replication requires the formation of replication complexes (RCs) consisting of virus-induced vesicles associated with viral nonstructural proteins and RNA.
Anderson, David A. +3 more
core +1 more source
An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes [PDF]
, 1996 In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes.
Aniento, F. +3 more
core +1 more source
Non-alcoholic fatty liver disease in mice with heterozygous mutation in TMED2.
PLoS ONE, 2017 The transmembrane emp24 domain/p24 (TMED) family are essential components of the vesicular transport machinery. Members of the TMED family serve as cargo receptors implicated in selection and packaging of endoplasmic reticulum (ER) luminal proteins into ...
Wenyang Hou +4 more
doaj +1 more source
Cell, 1991 ADP-ribosylation factor (ARF) is an abundant and highly conserved low molecular weight GTP-binding protein that was originally identified as a key element required for the action of cholera toxin in mammalian cells, but whose physiological role is unknown.
T, Serafini +5 more
openaire +2 more sources
Structural basis for the binding of tryptophan-based motifs by δ-COP. [PDF]
, 2015 Coatomer consists of two subcomplexes: the membrane-targeting, ADP ribosylation factor 1 (Arf1):GTP-binding βγδζ-COP F-subcomplex, which is related to the adaptor protein (AP) clathrin adaptors, and the cargo-binding αβ'ε-COP B-subcomplex. We present the
Duden, Rainer +7 more
core +1 more source
COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal [PDF]
, 2017 The COPI coat forms transport vesicles from the Golgi complex and plays a poorly defined role in endocytic trafficking. Here we show that COPI binds K63-linked polyubiquitin and this interaction is crucial for trafficking of a ubiquitinated yeast SNARE ...
Diab, Nicholas S +9 more
core +2 more sources