An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis [PDF]
, 2003 The protozoan parasite Giardia intestinalis belongs to one of the earliest diverged eukaryotic lineages. This is also reflected in a simple intracellular organization, as Giardia lacks common subcellular compartments such as mitochondria, peroxisomes ...
Hehl, Adrian B. +7 more
core +1 more source
eLife, 2017 COPI coated vesicles mediate trafficking within the Golgi apparatus and between the Golgi and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to the membrane ...
Svetlana O Dodonova +8 more
doaj +1 more source
Dissection of GTPase activating proteins reveals functional asymmetry in the COPI coat of budding yeast. [PDF]
, 2019 The Arf GTPase controls formation of the COPI vesicle coat. Recent structural models of COPI revealed the positioning of two Arf1 molecules in contrasting molecular environments.
Arakel, E. +5 more
core +1 more source
Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E. +4 more
core +2 more sources
An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes [PDF]
, 1996 In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes.
Aniento, F. +3 more
core +1 more source
Involvement of the transmembrane protein p23 in biosynthetic protein transport [PDF]
, 1997 The identification of ANO1/TMEM16A as the likely calcium-dependent chloride channel of exocrine glands has led to a more detailed understanding of its biophysical properties.
Alcalde +74 more
core +2 more sources
Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication [PDF]
, 2012 All positive strand RNA viruses are known to replicate their genomes in close association with intracellular membranes. In case of the hepatitis C virus (HCV), a member of the family Flaviviridae, infected cells contain accumulations of vesicles forming ...
Antony, Claude +13 more
core +3 more sources
Differential Requirements for COPI Coats in Formation of Replication Complexes among Three Genera of Picornaviridae [PDF]
, 2002 Picornavirus RNA replication requires the formation of replication complexes (RCs) consisting of virus-induced vesicles associated with viral nonstructural proteins and RNA.
Anderson, David A. +3 more
core +1 more source
Two Human ARFGAPs Associated with COP-I-Coated Vesicles
Traffic : the International Journal of Intracellular Transport, 2007 ADP‐ribosylation factors (ARFs) are critical regulators of vesicular trafficking pathways and act at multiple intracellular sites. ADP‐ribosylation factor‐GTPase‐activating proteins (ARFGAPs) are proposed to contribute to site‐specific regulation.
G. Frigerio +4 more
semanticscholar +1 more source
Non-alcoholic fatty liver disease in mice with heterozygous mutation in TMED2.
PLoS ONE, 2017 The transmembrane emp24 domain/p24 (TMED) family are essential components of the vesicular transport machinery. Members of the TMED family serve as cargo receptors implicated in selection and packaging of endoplasmic reticulum (ER) luminal proteins into ...
Wenyang Hou +4 more
doaj +1 more source