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Genetics of Primary CoQ10 Deficiency
Current Genomics, 2006Coenzyme Q (CoQ) is a lipophilic component of the mitochondrial respiratory enzyme chain, which transfers electrons to complex III (cytochrome bc complex) from complex I (NADH-CoQ reductase), complex II (succinate dehydrogenase), and from the oxidation of fatty acids and branched-chain amino acids via flavin-linked dehydrogenases.
Naini, Ali +4 more
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The role of CoQ10 in embryonic development
Journal of Assisted Reproduction and GeneticsCoenzyme Q10 (CoQ10) is a natural component widely present in the inner membrane of mitochondria. CoQ10 functions as a key cofactor for adenosine triphosphate (ATP) production and exhibits antioxidant properties in vivo. Mitochondria, as the energy supply center of cells, play a crucial role in germ cell maturation and embryonic development, a ...
Miao Jiang
exaly +3 more sources
Bioavailability of water-soluble CoQ10 in beagle dogs
Journal of Pharmaceutical and Biomedical Analysis, 2008The bioavailability of a novel water-soluble inclusion complex of CoQ10, prepared in our laboratory was determined and compared with the bioavailability of commercially available oil-based form of CoQ10. Experimental work consisted of single dose comparative bioavailability study on seven beagle dogs, with a 14-day washout period between treatments ...
Mirko Prosek, Andrej Smidovnik
exaly +3 more sources
Evaluation of Antioxidative Activity between CoQ10-Nanostructured Lipid Carrier and CoQ10 Cosmetic
Applied Mechanics and Materials, 2011Coenzyme Q10 (CoQ10) is a poorly water-soluble active ingredient with intrinsic chemical instability, but holds strongly antioxidative capacity. The CoQ10-NLC aqueous dispersion has been prepared, the antioxidative activity between CoQ10-NLC and CoQ10 cosmetic have been investigated, and several employed methods such as scavenging efficiency on DPPH ...
Jian Min Wang +6 more
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Efficacy of CoQ10 as supplementation for migraine: A meta-analysis
Acta Neurologica Scandinavica, 2018Migraine ranks among the most frequent neurological disorders globally. Co-enzyme Q10 (CoQ10) is a nutritional agent that might play a preventative role in migraine. This meta-analysis aimed to investigate the effects of CoQ10 as a supplemental agent in migraine.Web of Science, PubMed, and Cochrane Library were searched for potential articles that ...
ZhiYong Zeng +4 more
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Anti‐inflammatory effects of CoQ10 and colorless carotenoids
Journal of Cosmetic Dermatology, 2006SummaryBackground CoQ10 (ubiquinone, coenzyme Q10) and carotenoids are popular antioxidants used in many skin care products to protect the skin from free radical damage.Aim To evaluate the effects of CoQ10 and colorless carotenoids on the production of inflammatory mediators in human dermal fibroblasts treated with UV radiation (UVR) and to ...
Bryan, Fuller +3 more
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Formation of CoQ10 reduced form by mixing CoQ10 oxidized form γCD complex and vitamin C in powder
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2010We have already reported the enhancement of the stability and bioavailability of coenzyme Q10 (CoQ10) oxidized form by γ-cyclodextrin (γCD) complexation. In a series of the studies, we investigated an easy and economical conversion of CoQ10 oxidized form to its reduced form in complex powder, using inexpensive vitamin C (VC) as the reductant.
Yukiko Uekaji +7 more
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Skin penetration of CoQ10 in the rat.
International journal of tissue reactions, 1988Skin penetration of coenzyme Q10 (CoQ10) was investigated after topical treatment in the rat. The drug was suspended in olive oil and administered at two different concentrations. Coenzyme levels were found to be directly related to the concentrations employed and the contact time.
L, Giovannini +5 more
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Benefits of CoQ10 supplementation in patients with SRNS due to primary CoQ10 deficiency
Nature Reviews Nephrology, 2022openaire +2 more sources
CoQ10 in the Treatment of Heart and Vascular Disease
2003CoQ10 (CoQ10) deficiency has been reported in apparently healthy subjects as well as in patients with congestive heart failure, angina pectoris, coronary artery disease, cardiomyopathy, hypertension, mitral valve prolapse, diabetes mellitus and after coronary revascularization. Since CoQ10 bolsters the synthesis of ATP and inhibits free radical damage,
Ram B. Singh +7 more
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