Results 101 to 110 of about 470,683 (177)

Coq4 is an oxidative decarboxylase associated with coenzyme Q biosynthesis and mitochondrial function in Toxoplasma gondii

One Health Advances
As an obligate intracellular parasite, Toxoplasma gondii is a widely distributed zoonotic pathogen posing a substantial threat to both human and animal health. Interestingly, T.
Yuntong Wu, Zhu Ying, Yanqun Pei, Shiman Yang, Xudong Wang, Yong Fu, Qun Liu, Jing Liu   +7 more
doaj   +1 more source

Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease. [PDF]

J Clin Invest, 2021
Sidhom EH, Kim C, Kost-Alimova M, Ting MT, Keller K, Avila-Pacheco J, Watts AJ, Vernon KA, Marshall JL, Reyes-Bricio E, Racette M, Wieder N, Kleiner G, Grinkevich EJ, Chen F, Weins A, Clish CB, Shaw JL, Quinzii CM, Greka A.   +19 more
europepmc   +1 more source

Identification of a new COQ4 spliceogenic variant causing severe primary coenzyme Q deficiency

Molecular Genetics and Metabolism Reports
Background and aims: Primary Coenzyme Q (CoQ) deficiency caused by COQ4 defects is a clinically heterogeneous mitochondrial condition characterized by reduced levels of CoQ10 in tissues. Next-generation sequencing has lately boosted the genetic diagnosis
María Alcázar-Fabra, Elsebet Østergaard, Daniel J.M. Fernández-Ayala, María Andrea Desbats, Valeria Morbidoni, Laura Tomás-Gallado, Laura García-Corzo, María del Mar Blanquer-Roselló, Abigail K. Bartlett, Ana Sánchez-Cuesta, Lucía Sena, Ana Cortés-Rodríguez, María Victoria Cascajo-Almenara, David J. Pagliarini, Eva Trevisson, Sabine W. Gronborg, Gloria Brea-Calvo   +16 more
doaj   +1 more source

β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight. [PDF]

Biomedicines, 2021
Hidalgo-Gutiérrez A, Barriocanal-Casado E, Díaz-Casado ME, González-García P, Zenezini Chiozzi R, Acuña-Castroviejo D, López LC.   +6 more
europepmc   +1 more source

Tissue‐specific oxidative stress and loss of mitochondria in CoQ‐deficient Pdss2 mutant mice

The FASEB Journal, 2012
Primary human CoQ 10 deficiencies are clinically heterogeneous diseases caused by mutations in PDSS2 and other genes required for CoQ 10 biosynthesis.
Quinzii C. M., Garone C., Emmanuele V., Tadesse S., Krishna S., Dorado B., Hirano M.   +6 more
openaire   +3 more sources

Nano-granulated zoledronate sensitizes innate immune metabolism to enhance vaccine-induced and antitumor immunity

Cell Reports Medicine
Summary: Metabolic reprogramming targeting the mevalonate pathway represents an emerging innate immune activation target. However, its regulatory mechanisms remain incompletely elucidated.
Meifang Chen, Xiaojia Jiao, Zhicheng Yan, Yueheng Wang, Jing Zhang, Qinghua Wu, Minghui Li, Shumin Fan, Yuan Wang, Wenbing Dai, Hua Zhang, Xueqing Wang, Qiang Zhang, Bing He   +13 more
doaj   +1 more source

Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency

Frontiers in Physiology, 2017
Coenzyme Q is a lipid that participates to important physiological functions. Coenzyme Q is synthesized in multiple steps from the precursor 4-hydroxybenzoic acid.
Fabien Pierrel
doaj   +1 more source

Proofs You Can Believe In: Proving Equivalences Between Prolog Semantics in Coq [PDF]

, 2013
Basing program analyses on formal semantics has a long and successful tradition in the logic programming paradigm. These analyses rely on results about the relative correctness of mathematically sophisticated semantics, and authors of such analyses often
Jael Kriener, Andy King, Blazy, Sandrine, Sandrine Blazy, King, Andy, Kriener, Jael   +5 more
core   +1 more source

coq-community/trocq: Trocq 0.1.2

A modular parametricity plugin for proof transfer in Coq [maintainers=@CohenCyril,@ecranceMERCE ...
Cyril Cohen, Enzo Crance, Mahboubi, Assia   +2 more
core   +1 more source

Adaptation of mitochondrial bioenergetics to coenzyme Q deficiency in human endothelial cells after chronic exposure to bisphosphonates

Scientific Reports
Nitrogen-containing bisphosphonates (N-BPs), widely used in bone disease therapy, inhibit the mevalonate pathway, which affects coenzyme Q (CoQ) biosynthesis and may compromise mitochondrial function, particularly in endothelial cells where oxidative ...
Adrianna Budzinska, Lukasz Galganski, Krzysztof Wojcicki, Wieslawa Jarmuszkiewicz   +3 more
doaj   +1 more source