Results 81 to 90 of about 470,683 (177)

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

uds-psl/coq-library-undecidability: Coq Library of Undecidability Proofs version 1.1.1+8.18

, 2023
A library of mechanised undecidability proofs in the Coq proof ...
Yannick Forster, Dominik Kirst, Fabian Kunze, froozen, Johannes Matthias Hostert, haansn08, Lennard Gäher, Dominique Larchey-Wendling, Marc Hermes, Mark Koch, bn-peters, Andrej Dudenhefner, SohnyBohny   +12 more
core   +2 more sources

Travelling, Staying, Working, Imagining: Space and the Practice of Internationalism, c1900–1950

History Compass, Volume 24, Issue 5, October 2026.
ABSTRACT This article considers space as a key element in the practice of internationalism in the first half of the 20th century. Drawing on approaches in historical geography and cultural history, the article proposes four analytical categories through which internationalism might be explored in the period between 1900 and 1950.
Julia Eichenberg, Tomás Irish
wiley   +1 more source

Iron Homeostasis and Liver Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Iron is an essential micronutrient whose ability to cycle between ferric (Fe3+) and ferrous (Fe2+) states makes it crucial for physiological processes, including oxygen transport, DNA synthesis, and oxidative phosphorylation. However, because both deficiency and excess can cause severe pathology, precise regulation is critical. The liver plays
Peng Yang, Zhitian Shi, Qin Huang, Zhihong Tu, Yue Sun, Lin Wang, Yonglong Wei   +6 more
wiley   +1 more source

Defining Core Evidence‐Based Practice Knowledge for Health Professionals: A Delphi Consensus Study

Journal of Evaluation in Clinical Practice, Volume 32, Issue 7, October 2026.
ABSTRACT Rationale, Aims and Objectives A clearly defined content domain is needed to assess whether health professionals possess the conceptual knowledge required for Evidence‐Based Practice (EBP). Existing competency frameworks and assessment instruments often combine knowledge with skills, attitudes and behaviours, limiting the identification of ...
Clara Carbonell‐Crespí, Albert Sesé‐Abad, Esther Díaz‐Mohedo, Juan Carlos Fernández‐Domínguez   +3 more
wiley   +1 more source

Molecular diagnosis of coenzyme Q 10 deficiency: an update

, 2018
Introduction: Coenzyme Q 10 (CoQ) deficiency syndromes comprise a growing number of genetic disorders. While primary CoQ deficiency syndromes are rare diseases, secondary deficiencies have been related to both genetic and environmental conditions, which ...
Navas P., Yubero D., Salviati L., Artuch R., Montero R., Santos-Ocana C.   +5 more
core   +2 more sources

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders. [PDF]

, 2016
We evaluated the coenzyme Q10 (CoQ) levels in patients who were diagnosed with mitochondrial oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders (n=72).
Yubero, Pérez Dueñas B, Ortez C, Ramos F, Lopez Gallardo E, Garcia Villoria J, Hernández Laín A, Paradas Lópe C, Sánchez Cuesta A, González Quintana A, Colomer J, Brea Calvo G., García Cazorla A, Cascajo MV, Jou C, Cortés AB, Alcázar M, CoQ deficiency study group, TREVISSON, EVA, García Silva MT, Grazina M, Martín E, Morán M, Artuch R, Nascimento A, Neergheen V, Blázquez A, Ribes A, Rivas Infante E, Navas P, Marcé Grau A, Jimenez Mallebrera C, Pineda M, Delmiro A, Domínguez González C, Macaya A, Montero R, O'Callaghan M, Espinós C, Ávila Polo R, Hargreaves IP, Simões M, Arenas J, Rodriguez Aguilera JC, Diogo L, Martínez Fernández EM, Martín MA, SALVIATI, LEONARDO, Quijada P, Montoya J, Ruiz Pesini E, Bautista Lorite J, Arias A, Ruiz A, Emperador S, García-Cazorla, A., Ruiz, A., Ávila Polo, R., Montoya, J., Alcázar, M., Jou, C., Navas, Plácido, Macaya, A., Cascajo Almenara, M. V., Grazina, M., Sánchez-Cuesta, A., Pineda, M., Emperador, S., Brea-Calvo, G., Lopez-Gallardo, E., Martín, E., Jimenez-Mallebrera, C., Martínez Fernández, E. M., Marcé-Grau, A., Brea-Calvo, Gloria, Blázquez, A., Yubero, D., Montero, R., Alcázar-Fabra, María, O''Callaghan, M., Trevisson, E., Bautista Lorite, J., Delmiro, A., Ramos, F., Colomer, J., Quijada, P., Cascajo, M. V., Rivas Infante, Eloy, Salviati, L., Domínguez-González, C., Martín, Miguel A., Navas, P., Hernández-Laín, A., Rodríguez-Aguilera, Juan Carlos, Cortés, A. B., Espinós, C., Pérez-Dueñas, B., Rodriguez-Aguilera, J., Artuch, Rafael, Nascimento, A., Artuch, R., Simões, M., González-Quintana, A., Yubero, Delia, Rivas Infante, E., Paradas Lópe, C., Morán, M., García-Cazorla, Angels, Garcia-Villoria, J., Neergheen, V., Martín, M. A., Arenas, J., Ortez, C., Hargreaves, I. P., Ruiz-Pesini, E., Arias, A., Montero, Raquel, García-Silva, M. T., Ribes, A., Diogo, L.   +118 more
core   +1 more source

uds-psl/coq-library-undecidability: Trakhtenbrot in Coq, IJCAR 2020 selected papers (LMCS) v1.0

, 2021
A library of mechanised undecidability proofs in the Coq proof ...
Yannick Forster, Dominik Kirst, Dominique Larchey-Wendling, Fabian Kunze, Marc Hermes, Andrej Dudenhefner, lgaeher   +6 more
core   +1 more source

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial diseaseResearch in context

EBioMedicine, 2019
Background: The vast majority of mitochondrial disorders have limited the clinical management to palliative care. Rapamycin has emerged as a potential therapeutic drug for mitochondrial diseases since it has shown therapeutic benefits in a few mouse ...
Eliana Barriocanal-Casado, Agustín Hidalgo-Gutiérrez, Nuno Raimundo, Pilar González-García, Darío Acuña-Castroviejo, Germaine Escames, Luis C. López   +6 more
doaj   +1 more source