Results 71 to 80 of about 470,683 (177)

Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Marianna Maddaluno, Laura Cinque, Viviana Cetrangolo, Chiara De Leonibus   +3 more
wiley   +1 more source

Drought and soil macrofauna functional diversity effects on Mediterranean tree growth in an Ecotron ecosystem experiment

Functional Ecology, Volume 40, Issue 11, Page 3559-3576, November 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract The intensity, frequency and severity of drought events are projected to increase in the Mediterranean region under ongoing climate change. This may impact plant growth and survival in Mediterranean forests leading to altered ecosystem dynamics. The functional diversity
Justine Laoué, Alexandru Milcu, Johanne Nahmani, Sandra Barantal, Sylvain Coq, Nathalie Fromin, Emmanuel S. Gritti, Lenka Kovácsová, Stephan Hättenschwiler   +8 more
wiley   +1 more source

Association between genetic variants in the Coenzyme Q₁₀ metabolism and Coenzyme Q₁₀ status in humans

BMC Research Notes, 2011
Background Coenzyme Q10 (CoQ10) is essential for mitochondrial energy production and serves as an antioxidants in extra mitochondrial membranes. The genetics of primary CoQ10 deficiency has been described in several studies, whereas the influence of ...
Menke Thomas, Niklowitz Petra, Rimbach Gerald, Schmelzer Constance, Fischer Alexandra, Döring Frank   +5 more
doaj   +1 more source

Male mice are more susceptible than females to obesity‐induced muscle atrophy when fed a high‐fat, high‐cholesterol diet

Physiological Reports, Volume 14, Issue 21, November 2026.
Prolonged high‐fat, high‐cholesterol feeding makes male mice more susceptible than females to obesity‐induced muscle atrophy, driven by disrupted intestinal homeostasis and mitochondrial dysfunction. Abstract Obesity‐related skeletal muscle atrophy poses a significant health burden, with marked sex differences in this condition. However, the mechanisms
Tingyi Mo, Shan Wang, Zhixin Li, Haobin Xu, Xiaokang Liufu, Ya Wang, Nageena Qayyum, Honghui Guo   +7 more
wiley   +1 more source

An AlphaFold Structure Analysis of COQ2 as Key a Component of the Coenzyme Q Synthesis Complex

Antioxidants
Coenzyme Q (CoQ) is a lipidic compound that is widely distributed in nature, with crucial functions in metabolism, protection against oxidative damage and ferroptosis and other processes.
María de los Ángeles Vargas-Pérez, Damien Paul Devos, Guillermo López-Lluch   +2 more
doaj   +1 more source

Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function[S]

Journal of Lipid Research, 2019
Coenzyme Q (CoQ or ubiquinone) serves as an essential redox-active lipid in respiratory electron and proton transport during cellular energy metabolism.
Hui S. Tsui, NguyenV.B. Pham, Brendan R. Amer, Michelle C. Bradley, Jason E. Gosschalk, Marcus Gallagher-Jones, Hope Ibarra, Robert T. Clubb, Crysten E. Blaby-Haas, Catherine F. Clarke   +9 more
doaj   +1 more source

Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations

Redox Biology, 2020
Coenzyme Q10 (CoQ10; also known as ubiquinone) is a vital, redox-active membrane component that functions as obligate electron transporter in the mitochondrial respiratory chain, as cofactor in other enzymatic processes and as antioxidant.
Ying Wang, Siegfried Hekimi
doaj   +1 more source

Practical Guidelines for Diagnosing and Treating Thyroid Disease Based on the WOMED Metabolic Model of Disease Focusing on Glycolysis and Coenzyme Q₁₀ Deficiency—A Clinical Alternative to the 2021 Retired Clinical Practice Guidelines of the Endocrine Society

Diagnostics, 2022
This review aims to provide a functional, metabolic view of the pathogenesis of benign thyroid disease. Here, we summarize the features of our previous publications on the “WOMED model of benign thyroid disease”.
Roy Moncayo, Helga Moncayo
doaj   +1 more source

Decoding ferroptosis via integrated multi‐omics analyses in rice blast

iMeta, Volume 5, Issue 5, October 2026.
The rice‐Magnaporthe oryzae pathosystem is presented as a host‐pathogen ferroptosis model. Multi‐omics insights connect ferroptosis to several cellular processes, such as iron homeostasis, reactive oxygen species (ROS)/redox imbalance, and polyunsaturated fatty acid‐containing phospholipid (PUFA‐PL) peroxidation, under multiple regulators in rice and M.
Zhibin Liang, Qing Shen, Nam Khoa Nguyen, Ruhui Long, Yuming Ma, Qiao Liu, Naweed I. Naqvi, Nam‐Soo Jwa, Yi‐Zhen Deng   +8 more
wiley   +1 more source

Measuring Treatment Effectiveness in Real‐World Substance Use Care: A Community‐Based Program Evaluation

Journal of Addictions &Offender Counseling, Volume 47, Issue 2, Page 195-204, October 2026.
ABSTRACT This study reports findings from a community‐based program evaluation examining treatment effectiveness in a real‐world outpatient substance use care setting. Using a within‐program pre–post design, changes in alcohol and drug use were assessed among clients receiving intensive outpatient services.
Jessie A. Brown, Taryn M. Akgul, Todd F. Lewis, Patti Senn   +3 more
wiley   +1 more source