Corilagin ameliorates macrophages inflammation in atherosclerosis through TLR4-NFκB/MAPK pathway
Heliyon, 2023 Corilagin, a polyphenolic tannic acid compound, showed significant anti-inflammatory activity in atherosclerotic mice. The present study aimed to evaluate the effect and mechanism of corilagin in atherosclerosis by in vivo, in vitro and in molecular ...
Da Meng +7 more
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Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization [PDF]
Frontiers in Immunology, 2022 Immune-mediated hepatic injury plays a key role in the initiation and pathogenesis of diverse liver diseases. However, treatment choice for immune-mediated hepatic injury remains limited.
Fenglian Yan +16 more
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Corilagin attenuates the Parkinsonismin Japanese encephalitis virus induced Parkinsonism
Translational Neuroscience, 2018 This study evaluates the protective effect of corilagin against Parkinsonismin Japanese encephalitis virus (JEV) induced Parkinson’s disease. The JaGAr-01 strain of virus was used to induce JE.
Yanbing Ding +5 more
doaj +3 more sources
Corilagin in Cancer: A Critical Evaluation of Anticancer Activities and Molecular Mechanisms [PDF]
Molecules, 2019 Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose), an ellagitannin, is one of the major bioactive compounds present in various plants. Ellagitannins belong to the hydrolyzable tannins, a group of polyphenols.
Ashutosh Gupta +8 more
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Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase
Acta Pharmaceutica Sinica B, 2021 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become one major threat to human population health. The RNA-dependent RNA polymerase (RdRp) presents an ideal target of antivirals, whereas nucleoside analogs inhibitor is hindered by the ...
Quanjie Li +16 more
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In-silico and in-vitro studies to identify potential inhibitors of SARS-CoV-2 spike protein from Omani medicinal plants [PDF]
HeliyonIn the quest for novel therapeutic agents against SARS-CoV-2, the proposed study explores the potential of traditional Omani medicinal plants, focusing on the efficacy of natural ligands against the virus's Spike protein.
Nabras Al-Mahrami +7 more
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Longan flower water extract promotes sleep in mice via the serotonin-melatonin axis. [PDF]
J Sci Food AgricAbstract BACKGROUND Longan (Dimocarpus longan) flower is an underutilized botanical byproduct rich in polyphenols with reported neuroprotective actions, yet its role in sleep regulation remains unclear. This study aimed to evaluate the sleep‐promoting effects of longan flower water extract (LFWE) and its underlying neurochemical mechanisms in vivo ...
Hung TH +9 more
europepmc +2 more sources
Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway [PDF]
Cell Communication and Signaling, 2019 Background Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor, is essential for alleviating ...
Hongming Lv +5 more
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Corilagin potential in inhibiting oxidative and inflammatory stress in LPS-induced murine macrophage cell lines (RAW 264.7) [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Inflammation is thought to be the common pathophysiological basis for several disorders. Corilagin is one of the major active compounds which showed broad-spectrum biological and therapeutic activities, such as antitumor, hepatoprotective ...
Wahyu Widowati +7 more
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Biology, 2022 Acute lung injury (ALI) and acute respiratory distress syndrome are clinically life-threatening diseases. Corilagin, a major polyphenolic compound obtained from the herb Phyllanthus urinaria, has anti-inflammatory and antioxidant properties, and in this ...
Fu-Chao Liu +4 more
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