Results 21 to 30 of about 1,506 (156)

In-silico and in-vitro studies to identify potential inhibitors of SARS-CoV-2 spike protein from Omani medicinal plants [PDF]

Heliyon
In the quest for novel therapeutic agents against SARS-CoV-2, the proposed study explores the potential of traditional Omani medicinal plants, focusing on the efficacy of natural ligands against the virus's Spike protein.
Nabras Al-Mahrami, Smitha Sunil Kumaran Nair, Adhra Al Mawali, Raja-Mohamed Beema Shafreen, Saeed Ullah, Sobia Ahsan Halim, Ahmed Al-Harrasi, Nallusamy Sivakumar   +7 more
doaj   +2 more sources

Longan flower water extract promotes sleep in mice via the serotonin-melatonin axis. [PDF]

J Sci Food Agric
Abstract BACKGROUND Longan (Dimocarpus longan) flower is an underutilized botanical byproduct rich in polyphenols with reported neuroprotective actions, yet its role in sleep regulation remains unclear. This study aimed to evaluate the sleep‐promoting effects of longan flower water extract (LFWE) and its underlying neurochemical mechanisms in vivo ...
Hung TH, Cheng CP, Chiou WC, Hsia TL, Liu HK, Lu HF, Lai YH, Tsai ST, Chen CJ, Huang C.   +9 more
europepmc   +2 more sources

Corilagin potential in inhibiting oxidative and inflammatory stress in LPS-induced murine macrophage cell lines (RAW 264.7) [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Inflammation is thought to be the common pathophysiological basis for several disorders. Corilagin is one of the major active compounds which showed broad-spectrum biological and therapeutic activities, such as antitumor, hepatoprotective ...
Wahyu Widowati, Hanna Kusuma, Seila Arumwardana, Ervi Afifah, Cintani Wahyuni, Cahyaning Wijayanti, Muhamad Maulana, Rizal Rizal   +7 more
doaj   +1 more source

Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-κB Signaling Pathways in a Mouse Model

Biology, 2022
Acute lung injury (ALI) and acute respiratory distress syndrome are clinically life-threatening diseases. Corilagin, a major polyphenolic compound obtained from the herb Phyllanthus urinaria, has anti-inflammatory and antioxidant properties, and in this ...
Fu-Chao Liu, Chia-Chih Liao, Hung-Chen Lee, An-Hsun Chou, Huang-Ping Yu   +4 more
doaj   +1 more source

A network-based analysis of key pharmacological pathways of Corilagin acting on Breast cancer and experimental validation [PDF]

E3S Web of Conferences, 2020
The combination of network pharmacological methods and experimental verification has revealed the underlying molecular mechanism of Corilagin in the treatment of breast cancer.
Zhong Xue, Tang Jintian, Long Wenyue, Cai Xu, Wang Huiguo, Li Qian   +5 more
doaj   +1 more source

Corilagin: A Novel Antivirulence Strategy to Alleviate Streptococcus pneumoniae Infection by Diminishing Pneumolysin Oligomers

Molecules, 2022
Pneumolysin (PLY) is a significant virulence factor of Streptococcus pneumoniae (S. pneumoniae), able to break through the defense system of a host and mediate the occurrence of a series of infections. Therefore, PLY as the most ideal target to prevent S.
Qiushuang Sheng, Xiaoning Hou, Nan Wang, Minda Liu, Haoyu Zhu, Xuming Deng, Xiaoying Liang, Gefu Chi   +7 more
doaj   +1 more source

Role of NADPH Oxidase-Derived ROS-Mediated IL-6/STAT3 and MAPK/NF-κB Signaling Pathways in Protective Effect of Corilagin against Acetaminophen-Induced Liver Injury in Mice

Biology, 2023
Acetaminophen (APAP) overdose causes acute liver injury via oxidative stress, uncontrolled inflammatory response, and subsequent hepatocyte death. Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a potent source of cellular reactive oxygen ...
Fu-Chao Liu, Hung-Chen Lee, Chia-Chih Liao, An-Hsun Chou, Huang-Ping Yu   +4 more
doaj   +1 more source

Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis

Frontiers in Pharmacology, 2022
Intestinal ischemia reperfusion (II/R) is a clinical emergency that frequently occurs in a variety of clinical conditions. Severe intestinal injury results in the release of cytotoxic substances and inflammatory mediators which can activate local ...
Wenlian Li, Kejia Yang, Bin Li, Bin Li, Yunxiang Wang, Jing Liu, Jing Liu, Dapeng Chen, Yunpeng Diao, Yunpeng Diao   +9 more
doaj   +1 more source

Uji molecular docking dan bioinformatika terhadap meniran (Phyllanthus niruri L.) sebagai antivirus SARS-CoV-2 dan antikanker serviks

Menara Perkebunan, 2022
The SARS-CoV-2 virus is a virus that emerged in late 2019 and has yet to find a cure. On the other hand, the incidence of cervical cancer in women continues to increase along with the emergence of cases of COVID-19 caused by SARS-CoV-2. Based on WHO data
Nuha Haifa Arifin, Rifki Febriansah
doaj   +1 more source

Corilagin Ameliorates Atherosclerosis in Peripheral Artery Disease via the Toll-Like Receptor-4 Signaling Pathway in vitro and in vivo

Frontiers in Immunology, 2020
We investigated if corilagin can ameliorate or reverse atherosclerotic development via the toll-like receptor 4 (TLR4) signaling pathway in vitro and in vivo.
Yiqing Li, Yujie Wang, Yunfei Chen, Yao Wang, Shaojun Zhang, Pan Liu, Zhilin Chen, Peng Song, Lei Luo, Yingying Luo, Yiping Dang, Lei Zhao   +11 more
doaj   +1 more source