Results 21 to 30 of about 2,734 (188)

A network-based analysis of key pharmacological pathways of Corilagin acting on Breast cancer and experimental validation [PDF]

E3S Web of Conferences, 2020
The combination of network pharmacological methods and experimental verification has revealed the underlying molecular mechanism of Corilagin in the treatment of breast cancer.
Zhong Xue, Tang Jintian, Long Wenyue, Cai Xu, Wang Huiguo, Li Qian   +5 more
doaj   +1 more source

Corilagin: A Novel Antivirulence Strategy to Alleviate Streptococcus pneumoniae Infection by Diminishing Pneumolysin Oligomers

Molecules, 2022
Pneumolysin (PLY) is a significant virulence factor of Streptococcus pneumoniae (S. pneumoniae), able to break through the defense system of a host and mediate the occurrence of a series of infections. Therefore, PLY as the most ideal target to prevent S.
Qiushuang Sheng, Xiaoning Hou, Nan Wang, Minda Liu, Haoyu Zhu, Xuming Deng, Xiaoying Liang, Gefu Chi   +7 more
doaj   +1 more source

Role of NADPH Oxidase-Derived ROS-Mediated IL-6/STAT3 and MAPK/NF-κB Signaling Pathways in Protective Effect of Corilagin against Acetaminophen-Induced Liver Injury in Mice

Biology, 2023
Acetaminophen (APAP) overdose causes acute liver injury via oxidative stress, uncontrolled inflammatory response, and subsequent hepatocyte death. Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a potent source of cellular reactive oxygen ...
Fu-Chao Liu, Hung-Chen Lee, Chia-Chih Liao, An-Hsun Chou, Huang-Ping Yu   +4 more
doaj   +1 more source

Corilagin Attenuates Aerosol Bleomycin-Induced Experimental Lung Injury [PDF]

International Journal of Molecular Sciences, 2014
Idiopathic pulmonary fibrosis (IPF) is a progressing lethal disease with few clinically effective therapies. Corilagin is a tannin derivative which shows anti-inflammatory and antifibrotics properties and is potentiated in treating IPF. Here, we investigated the effect of corilagin on lung injury following bleomycin exposure in an animal model of ...
Wang, Zheng, Guo, Qiong-Ya, Zhang, Xiao-Ju, Li, Xiao, Li, Wen-Ting, Ma, Xi-Tao, Ma, Li-Jun   +6 more
openaire   +2 more sources

Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis

Frontiers in Pharmacology, 2022
Intestinal ischemia reperfusion (II/R) is a clinical emergency that frequently occurs in a variety of clinical conditions. Severe intestinal injury results in the release of cytotoxic substances and inflammatory mediators which can activate local ...
Wenlian Li, Kejia Yang, Bin Li, Bin Li, Yunxiang Wang, Jing Liu, Jing Liu, Dapeng Chen, Yunpeng Diao, Yunpeng Diao   +9 more
doaj   +1 more source

Bioactivity-Guided Isolation of β-Sitosterol From Terminalia glabrescens as a Potent Anti-Zika Virus Agent. [PDF]

Chem Biodivers
ABSTRACT Zika virus (ZIKV) infection remains a global health concern due to its neurological complications and the lack of specific drugs or vaccines. This study investigated the anti‐ZIKV potential of an ethanolic extract from Terminalia glabrescens leaves.
Pereira RS, Campana PRV, Costa VV, Maltarollo VG, de Pádua RM, de Gomes JHS, de Sousa GF, de Souza Filho JD, de Souza DDG, Teixeira MM, Braga FC.   +10 more
europepmc   +2 more sources

Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding

Phytomedicine, 2021
The outbreak of coronavirus (SARS-CoV-2) disease caused more than 100,000,000 people get infected and over 2,200,000 people being killed worldwide. However, the current developed vaccines or drugs may be not effective in preventing the pandemic of COVID-19 due to the mutations of coronavirus and the severe side effects of the newly developed vaccines ...
Li Jun Yang, Rui Hong Chen, Sami Hamdoun, Paolo Coghi, Jerome P.L. Ng, David Wei Zhang, Xiaoling Guo, Chenglai Xia, Betty Yuen Kwan Law, Vincent Kam Wai Wong   +9 more
openaire   +2 more sources

Uji molecular docking dan bioinformatika terhadap meniran (Phyllanthus niruri L.) sebagai antivirus SARS-CoV-2 dan antikanker serviks

Menara Perkebunan, 2022
The SARS-CoV-2 virus is a virus that emerged in late 2019 and has yet to find a cure. On the other hand, the incidence of cervical cancer in women continues to increase along with the emergence of cases of COVID-19 caused by SARS-CoV-2. Based on WHO data
Nuha Haifa Arifin, Rifki Febriansah
doaj   +1 more source

Corilagin induces apoptosis and autophagy in NRF2‑addicted U251 glioma cell line

Molecular Medicine Reports, 2021
Corilagin, extracted from the Euphorbiaceae and Phyllanthus plants, inhibits the growth of a number of types of tumors. Compared with temozolomide, the traditional chemotherapy drug, corilagin has demonstrated stronger antitumor activity. However, the pharmaceutical mechanism of corilagin in glioma remains unclear.
Liu, Jilan, Qin, Xianyun, Ma, Wenyuan, Jia, Shu, Zhang, Xiaobei, Yang, Xinlin, Pan, Dongfeng, Jin, Feng   +7 more
openaire   +3 more sources

Corrigendum to "Hepatoprotective Effect and Potential Mechanism of Aqueous Extract from <i>Phyllanthus emblica</i> on Carbon-Tetrachloride-Induced Liver Fibrosis in Rats". [PDF]

Evid Based Complement Alternat Med
Evidence-Based Complementary and Alternative Medicine, Volume 2025, Issue 1, 2025.
europepmc   +2 more sources